Complex α-thalassemia-like syndrome: A cause of neonatal normoblastemia

Michael K. McCormack, Gary R. Geller, Solomon Zak, David P. Tukey, William Krivit

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1 Scopus citations


A previously unrecognized hypochromic anemia associated with marked normoblastemia during the newborn period is reported. One male and two female siblings and a first cousin had a hypochromic anemia and marked normoblastemia (300 to 900 normoblast index per 100 white blood cells) at birth. Globin chain synthesis studies on peripheral blood of the proband at birth indicated the presence of α-thalassemia trait with possible reduced γ chain synthesis. Studies of globin chain synthesis on the father, two older affected siblings of the proband, and the proband at 1.5 years of age revealed α-thalassemia trait. The data suggest this complex α-thalassemia-like condition as a new syndrome associated with marked neonatal normoblastemia.

Original languageEnglish (US)
Pages (from-to)446-451
Number of pages6
JournalThe Journal of Pediatrics
Issue number3
StatePublished - Sep 1976
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health


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