Combinatorial screening of 3d printable bioinks for cartilage repair

Jonathan H. Galarraga, Sebastian Vega Fuentes, Mi Y. Kwon, Jason A. Burdick

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: 3D printing is a promising approach for the engineering of tissues; however, the identification of bioinks with the requisite printability, cytocompatibility, and bioactivity remains an ongoing challenge.1 To this end, we recently developed a 3D printing approach that permits the extrusion and deposition of non-viscous, photocrosslinkable materials with high fidelity and encapsulated cell viability.2 Specifically, we directly cured bioinks in situ with light during extrusion to print hyaluronic (HA)-based hydrogels into 3D structures. This approach allows the printing of a wide range of photocrosslinkable hydrogel bioinks. Here, we combined this approach with a combinatorial hydrogel screening process3 to first identify and then 3D print bioinks that optimize the behavior of chondrocytes (CHs) or mesenchymal stromal cells (MSCs) through control over the cell microenvironment.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Hydrogel
Cartilage
Hydrogels
Printing
Screening
Repair
Cellular Microenvironment
Extrusion
Tissue Engineering
Chondrocytes
Mesenchymal Stromal Cells
Bioactivity
Light
Tissue
Three Dimensional Printing

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Galarraga, J. H., Vega Fuentes, S., Kwon, M. Y., & Burdick, J. A. (2019). Combinatorial screening of 3d printable bioinks for cartilage repair. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.
Galarraga, Jonathan H. ; Vega Fuentes, Sebastian ; Kwon, Mi Y. ; Burdick, Jason A. / Combinatorial screening of 3d printable bioinks for cartilage repair. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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Galarraga, JH, Vega Fuentes, S, Kwon, MY & Burdick, JA 2019, Combinatorial screening of 3d printable bioinks for cartilage repair. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.

Combinatorial screening of 3d printable bioinks for cartilage repair. / Galarraga, Jonathan H.; Vega Fuentes, Sebastian; Kwon, Mi Y.; Burdick, Jason A.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Galarraga JH, Vega Fuentes S, Kwon MY, Burdick JA. Combinatorial screening of 3d printable bioinks for cartilage repair. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).