TY - GEN
T1 - Combinatorial screening of 3d printable bioinks for cartilage repair
AU - Galarraga, Jonathan H.
AU - Vega, Sebastian L.
AU - Kwon, Mi Y.
AU - Burdick, Jason A.
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: 3D printing is a promising approach for the engineering of tissues; however, the identification of bioinks with the requisite printability, cytocompatibility, and bioactivity remains an ongoing challenge.1 To this end, we recently developed a 3D printing approach that permits the extrusion and deposition of non-viscous, photocrosslinkable materials with high fidelity and encapsulated cell viability.2 Specifically, we directly cured bioinks in situ with light during extrusion to print hyaluronic (HA)-based hydrogels into 3D structures. This approach allows the printing of a wide range of photocrosslinkable hydrogel bioinks. Here, we combined this approach with a combinatorial hydrogel screening process3 to first identify and then 3D print bioinks that optimize the behavior of chondrocytes (CHs) or mesenchymal stromal cells (MSCs) through control over the cell microenvironment.
AB - Statement of Purpose: 3D printing is a promising approach for the engineering of tissues; however, the identification of bioinks with the requisite printability, cytocompatibility, and bioactivity remains an ongoing challenge.1 To this end, we recently developed a 3D printing approach that permits the extrusion and deposition of non-viscous, photocrosslinkable materials with high fidelity and encapsulated cell viability.2 Specifically, we directly cured bioinks in situ with light during extrusion to print hyaluronic (HA)-based hydrogels into 3D structures. This approach allows the printing of a wide range of photocrosslinkable hydrogel bioinks. Here, we combined this approach with a combinatorial hydrogel screening process3 to first identify and then 3D print bioinks that optimize the behavior of chondrocytes (CHs) or mesenchymal stromal cells (MSCs) through control over the cell microenvironment.
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M3 - Conference contribution
AN - SCOPUS:85065431497
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 419
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -