Collateral projection from the locus coeruleus to whisker-related sensory and motor brain regions of the rat

Sat Byol Lee, Suk K. Beak, Seung H. Park, Barry D. Waterhouse, Hyun S. Lee

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The primary goal of this study was to examine whether the locus coeruleus (LC) provides collateral projections to whisker-related, sensorimotor brain regions. After injections of retrograde tracers into the primary sensory (S1) barrel field/primary whisker motor (M1) cortices, ventroposteromedial (VPM)/ventrolateral (VL) thalamic nuclei, or principal sensory trigeminal (Pr5)/facial motor (Mo7) nuclei, the distribution of double-labeled neurons within the LC was examined. Our observations indicated that a large number of individual LC cells provided axon collaterals to S1-M1 or VPM-VL regions, whereas only a few projected to Pr5-Mo7 nuclei. The laterality and the distribution of dual-projecting LC neurons were as follows. 1) The neurons projecting to the S1-M1 cortices were predominantly ipsilateral (96% ± 0.7%). Labeled neurons were located ventrally at the rostral pole but were evenly distributed along the dorsoventral aspect of the principal LC. 2) The cells projecting to the VPM-VL nuclei were bilateral, with ipsilateral (68% ± 2.3%) dominance. Neurons were observed at the rostrocaudal extent of the LC, where the labeling was most pronounced at the ventral, principal LC. 3) The neurons projecting to the Pr5-Mo7 regions exhibited slightly contralateral (56% ± 2.9%) dominance, where labeled cells were confined within the ventral margin of the principal subdivision. Taken together, the present observations demonstrate that each subdivision of the LC possesses a differential functional organization with respect to its collateral projection to whisker-related sensorimotor targets, suggesting that the nucleus might play a modulatory role in vibrissal sensorimotor integration that allows the guidance of behavioral action essential for the survival of the animal.

Original languageEnglish (US)
Pages (from-to)387-402
Number of pages16
JournalJournal of Comparative Neurology
Volume514
Issue number4
DOIs
StatePublished - Jun 1 2009

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Vibrissae
Locus Coeruleus
Brain
Neurons
Ventral Thalamic Nuclei
Motor Cortex
Axons
Injections

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

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title = "Collateral projection from the locus coeruleus to whisker-related sensory and motor brain regions of the rat",
abstract = "The primary goal of this study was to examine whether the locus coeruleus (LC) provides collateral projections to whisker-related, sensorimotor brain regions. After injections of retrograde tracers into the primary sensory (S1) barrel field/primary whisker motor (M1) cortices, ventroposteromedial (VPM)/ventrolateral (VL) thalamic nuclei, or principal sensory trigeminal (Pr5)/facial motor (Mo7) nuclei, the distribution of double-labeled neurons within the LC was examined. Our observations indicated that a large number of individual LC cells provided axon collaterals to S1-M1 or VPM-VL regions, whereas only a few projected to Pr5-Mo7 nuclei. The laterality and the distribution of dual-projecting LC neurons were as follows. 1) The neurons projecting to the S1-M1 cortices were predominantly ipsilateral (96{\%} ± 0.7{\%}). Labeled neurons were located ventrally at the rostral pole but were evenly distributed along the dorsoventral aspect of the principal LC. 2) The cells projecting to the VPM-VL nuclei were bilateral, with ipsilateral (68{\%} ± 2.3{\%}) dominance. Neurons were observed at the rostrocaudal extent of the LC, where the labeling was most pronounced at the ventral, principal LC. 3) The neurons projecting to the Pr5-Mo7 regions exhibited slightly contralateral (56{\%} ± 2.9{\%}) dominance, where labeled cells were confined within the ventral margin of the principal subdivision. Taken together, the present observations demonstrate that each subdivision of the LC possesses a differential functional organization with respect to its collateral projection to whisker-related sensorimotor targets, suggesting that the nucleus might play a modulatory role in vibrissal sensorimotor integration that allows the guidance of behavioral action essential for the survival of the animal.",
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Collateral projection from the locus coeruleus to whisker-related sensory and motor brain regions of the rat. / Lee, Sat Byol; Beak, Suk K.; Park, Seung H.; Waterhouse, Barry D.; Lee, Hyun S.

In: Journal of Comparative Neurology, Vol. 514, No. 4, 01.06.2009, p. 387-402.

Research output: Contribution to journalArticle

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AU - Beak, Suk K.

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