Clinical research in the lay press: Irresponsible journalism raises a huge dose of doubt

Elias J. Anaissie; Brahm H. Segal; John R. Graybill; Carola Arndt; John R. Perfect; Michael Kleinberg; Peter Pappas; Danny Benjamin; Robert Rubin; Judith A. Aberg; Elisabeth E. Adderson; Felice C. Adler-Shohet; Hamdi Akan; Murat Akova; Nikolaos G. Almyroudis; Barbara D. Alexander; David Andes; Antonio Arrieta; John W. Baddley; Michelle A. Barron; Howard Belzberg; Helen W. Boucher; Thomas G. Boyce; Arturo Casadevall; P. H. Chandrasekar; John D. Cleary; Catherine Cordonnier; Oliver A. Cornely; Manuel Cuenca-Estrella; Jennifer S. Daly; Nicholas Daoura; David W. Denning; Ben DePauw; Louis De Repentigny; Maria Cecilia Dignani; William E. Dismukes; J. Peter Donnelly; Gerald R. Donowitz; Bertrand Dupont; George Drusano; Michael Ellis; Ana Espinel-Ingroff; Jay A. Fishman; Rhonda Fleming; Graeme Forrest; Mahmoud Ghannoum; Mitchell Goldman; Monica Grazziutti; John H. Greene; Richard N. Greenberg; Paul O. Gubbins; Susan Hadley; Raoul Herbrecht; John W. Hiemenz; William Hope; Durane R. Hospenthal; Shahid Husain; James I. Ito; Robert M. Jacobson; Melissa Johnson; Michael R. Keating; Daniel H. Kett; Katherine Knapp; Dimitrios P. Kontoyiannis; Vladimir C. Krcmery; Robert Larsen; Michel Laverdiere; Per Ljungman; O. Lortholary; Johan Maertens; Debbie Marriott; Gloria Mattiuzzi; Michael R. McGinnis; Michele Morris; Marcio Nucci; Frank C. Odds; George A. Pankey; Thomas Patterson; Mike Pfaller; Raymond R. Razonable; Annette C. Reboli; Michael G. Rinaldi; Glenn D. Roberts; Juan Luis Rodriguez Tudela; Coleman Rotstein; Markus Ruhnke; Mindy Schuster; Shmuel Shoham; Irene G. Sia; Nita Siebel; Fernanda Silviera; Nina Singh; Jack Sobel; Joseph S. Solomkin; Tania C. Sorrell; William J. Steinbach; Zelalem Temesgen; Annamaria Tortorano; Shahe Vartivarian; Paul Verweij; Claudio Viscoli; Maria Anna Viviani; Randall C. Walker; Joseph L. Wheat; Joseph Wiley; Peter Williamson; John R. Wingard; Victor L. Yu; Theoklis Zaoutis

doi:10.1086/509116

Clinical research in the lay press: Irresponsible journalism raises a huge dose of doubt

Elias J. Anaissie, Brahm H. Segal, John R. Graybill, Carola Arndt, John R. Perfect, Michael Kleinberg, Peter Pappas, Danny Benjamin, Robert Rubin, Judith A. Aberg, Elisabeth E. Adderson, Felice C. Adler-Shohet, Hamdi Akan, Murat Akova, Nikolaos G. Almyroudis, Barbara D. Alexander, David Andes, Antonio Arrieta, John W. Baddley, Michelle A. BarronHoward Belzberg, Helen W. Boucher, Thomas G. Boyce, Arturo Casadevall, P. H. Chandrasekar, John D. Cleary, Catherine Cordonnier, Oliver A. Cornely, Manuel Cuenca-Estrella, Jennifer S. Daly, Nicholas Daoura, David W. Denning, Ben DePauw, Louis De Repentigny, Maria Cecilia Dignani, William E. Dismukes, J. Peter Donnelly, Gerald R. Donowitz, Bertrand Dupont, George Drusano, Michael Ellis, Ana Espinel-Ingroff, Jay A. Fishman, Rhonda Fleming, Graeme Forrest, Mahmoud Ghannoum, Mitchell Goldman, Monica Grazziutti, John H. Greene, Richard N. Greenberg, Paul O. Gubbins, Susan Hadley, Raoul Herbrecht, John W. Hiemenz, William Hope, Durane R. Hospenthal, Shahid Husain, James I. Ito, Robert M. Jacobson, Melissa Johnson, Michael R. Keating, Daniel H. Kett, Katherine Knapp, Dimitrios P. Kontoyiannis, Vladimir C. Krcmery, Robert Larsen, Michel Laverdiere, Per Ljungman, O. Lortholary, Johan Maertens, Debbie Marriott, Gloria Mattiuzzi, Michael R. McGinnis, Michele Morris, Marcio Nucci, Frank C. Odds, George A. Pankey, Thomas Patterson, Mike Pfaller, Raymond R. Razonable, Annette C. Reboli, Michael G. Rinaldi, Glenn D. Roberts, Juan Luis Rodriguez Tudela, Coleman Rotstein, Markus Ruhnke, Mindy Schuster, Shmuel Shoham, Irene G. Sia, Nita Siebel, Fernanda Silviera, Nina Singh, Jack Sobel, Joseph S. Solomkin, Tania C. Sorrell, William J. Steinbach, Zelalem Temesgen, Annamaria Tortorano, Shahe Vartivarian, Paul Verweij, Claudio Viscoli, Maria Anna Viviani, Randall C. Walker, Joseph L. Wheat, Joseph Wiley, Peter Williamson, John R. Wingard, Victor L. Yu, Theoklis Zaoutis

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Original language	English (US)
Pages (from-to)	1031-1039
Number of pages	9
Journal	Clinical Infectious Diseases
Volume	43
Issue number	8
DOIs	https://doi.org/10.1086/509116
State	Published - Oct 15 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

Access to Document

10.1086/509116

Cite this

Anaissie, E. J., Segal, B. H., Graybill, J. R., Arndt, C., Perfect, J. R., Kleinberg, M., Pappas, P., Benjamin, D., Rubin, R., Aberg, J. A., Adderson, E. E., Adler-Shohet, F. C., Akan, H., Akova, M., Almyroudis, N. G., Alexander, B. D., Andes, D., Arrieta, A., Baddley, J. W., ... Zaoutis, T. (2006). Clinical research in the lay press: Irresponsible journalism raises a huge dose of doubt. Clinical Infectious Diseases, 43(8), 1031-1039. https://doi.org/10.1086/509116

@article{a959c5332a6c4063b3c4e4d4fc7161fe,

title = "Clinical research in the lay press: Irresponsible journalism raises a huge dose of doubt",

author = "Anaissie, {Elias J.} and Segal, {Brahm H.} and Graybill, {John R.} and Carola Arndt and Perfect, {John R.} and Michael Kleinberg and Peter Pappas and Danny Benjamin and Robert Rubin and Aberg, {Judith A.} and Adderson, {Elisabeth E.} and Adler-Shohet, {Felice C.} and Hamdi Akan and Murat Akova and Almyroudis, {Nikolaos G.} and Alexander, {Barbara D.} and David Andes and Antonio Arrieta and Baddley, {John W.} and Barron, {Michelle A.} and Howard Belzberg and Boucher, {Helen W.} and Boyce, {Thomas G.} and Arturo Casadevall and Chandrasekar, {P. H.} and Cleary, {John D.} and Catherine Cordonnier and Cornely, {Oliver A.} and Manuel Cuenca-Estrella and Daly, {Jennifer S.} and Nicholas Daoura and Denning, {David W.} and Ben DePauw and {De Repentigny}, Louis and Dignani, {Maria Cecilia} and Dismukes, {William E.} and Donnelly, {J. Peter} and Donowitz, {Gerald R.} and Bertrand Dupont and George Drusano and Michael Ellis and Ana Espinel-Ingroff and Fishman, {Jay A.} and Rhonda Fleming and Graeme Forrest and Mahmoud Ghannoum and Mitchell Goldman and Monica Grazziutti and Greene, {John H.} and Greenberg, {Richard N.} and Gubbins, {Paul O.} and Susan Hadley and Raoul Herbrecht and Hiemenz, {John W.} and William Hope and Hospenthal, {Durane R.} and Shahid Husain and Ito, {James I.} and Jacobson, {Robert M.} and Melissa Johnson and Keating, {Michael R.} and Kett, {Daniel H.} and Katherine Knapp and Kontoyiannis, {Dimitrios P.} and Krcmery, {Vladimir C.} and Robert Larsen and Michel Laverdiere and Per Ljungman and O. Lortholary and Johan Maertens and Debbie Marriott and Gloria Mattiuzzi and McGinnis, {Michael R.} and Michele Morris and Marcio Nucci and Odds, {Frank C.} and Pankey, {George A.} and Thomas Patterson and Mike Pfaller and Razonable, {Raymond R.} and Reboli, {Annette C.} and Rinaldi, {Michael G.} and Roberts, {Glenn D.} and {Rodriguez Tudela}, {Juan Luis} and Coleman Rotstein and Markus Ruhnke and Mindy Schuster and Shmuel Shoham and Sia, {Irene G.} and Nita Siebel and Fernanda Silviera and Nina Singh and Jack Sobel and Solomkin, {Joseph S.} and Sorrell, {Tania C.} and Steinbach, {William J.} and Zelalem Temesgen and Annamaria Tortorano and Shahe Vartivarian and Paul Verweij and Claudio Viscoli and Viviani, {Maria Anna} and Walker, {Randall C.} and Wheat, {Joseph L.} and Joseph Wiley and Peter Williamson and Wingard, {John R.} and Yu, {Victor L.} and Theoklis Zaoutis",

note = "Funding Information: ceived grant support from Astellas, Curagen, En-zon, Nuvelo, Orthobiotech, and Pfizer, is a consultant for Astellas, Gilead Sciences, Merck, Pfizer, and Schering Plough, and is a member of the speaker{\textquoteright}s bureau for Astellas, Gilead Sciences, Merck, Pfizer, and Schering Plough. B.H.S. has received grant support from Astellas, is a consultant for Enzon and Schering Plough, and is a member of the speaker{\textquoteright}s bureau for Merck and Pfizer. J.R.G. has received grant support from Aro-nex, Vicuron, Pfizer, Schering, Fujisawa, Astellas, F2G, Merck, and Indevus, is a consultant for Aro-nex, Vicuron, Pfizer, Schering, Fujisawa, Astellas, F2G, Merck, Indevus, Abbott, and Glaxo-SmithKline, and is a member of the speaker{\textquoteright}s bureau for Pfizer, Schering, and F2G. C.A. is a stockholder in Merck. J.R.P. has received grant support from Merck, Enzon, Astellas, Schering Plough, and Pfizer and is a consultant for Merck, Enzon, As-tellas, Schering Plough, and Pfizer. M.K. has received grant support from Pfizer and is a member of the speaker{\textquoteright}s bureau for Pfizer and Enzon. D.B. has received grant support from Astellas, Med-Immune, Pediatrix, Rocketasher Research, Astra Zeneca, Johnson & Johnson, Pfizer, and Vicuron. J.A.A. has received grant support from Bristol My-ers Squibb, Gilead, Abbott, Roche, Berlex Labs, Merck, GlaxoSmithKline, and Tibotec and is a consultant for Bristol Myers Squibb, Gilead, Abbott, GlaxoSmithKline, and Boehringer Ingelheim. B.D.A. has received grant support from Astellas and Enzon, is a consultant for Astellas, Pfizer, Sch-ering Plough, Enzon, Bristol Myers Squibb/Eisai Medical Research, Cubicin, Merck, Novartis,Phar- macia, Roche, Vircuron, and Viropharma, and is a member of the speaker{\textquoteright}s bureau for Astellas, Pfizer, Schering Plough, and OrthoBiotec. D.A. has received grant support from Astellas, Pfizer, En-zon, Schering, GlaxoSmithKline, and Merck, is a consultant for Pfizer, Schering Plough, and Merck, and is a member of the speaker{\textquoteright}s bureau for Pfizer and Merck. J.W.B. has received grant support from Merck and Astellas, is a consultant for Merck, and is a member of the speaker{\textquoteright}s bureau for Enzon, Merck, and Pfizer. M.A.B. has received grant support from Astellas, Cubist, Genzyme, and Merck, is a consultant for Astellas, Abbott, Pfizer, Merck, and Schering Plough, and is a member of the speaker{\textquoteright}s bureau for Astellas, Abbott, Pfizer, Merck, and Schering Plough. H.W.B. is a consultant for Cubist Pharmaceuticals, Pfizer, As-preva, Aspreva Pharmaceuticals, and Schering Plough, is a member of the speaker{\textquoteright}s bureau for Cubist Pharmaceuticals, Pfizer, Aspreva, Aspreva Pharmaceuticals, and Schering Plough, and is a stock holder in Cubist. T.G.B. is a member of the speaker{\textquoteright}s bureau for Abbott, MedImmune, Pfizer, and Sanofi-Pasteur. A.C. has received grant support from Pfizer and Energy Dynamics and is a consultant for Pfizer, Merck, Wyeth, Bioveris, and Energy Dynamics. O.A.C. has received grant support from Astellas, Basilea, Gilead, Pfizer, Merck, Schering Plough, and Vicuron, is a consultant for Astellas, Basilea, Gilead, Pfizer, Merck, Nektar, and Schering Plough, and is a member of the speaker{\textquoteright}s bureau for Astellas, Gilead, Merck, and Schering Plough. M.C.-E. has received grant support from Pfizer, Merck, Schering Plough, and Gilead and is a member of the speaker{\textquoteright}s bureau for Gilead, Merck, Pfizer, and Schering Plough. J.S.D. has received grant support from Merck and Schering Plough. L.d.R. has received grant support from the Canadian Institute of Health. M.C.D. is a member of the speaker{\textquoteright}s bureau for Pfizer. W.E.D. has received grant support from Merck and Astellas, is a consultant for Astellas and Pfizer, and is a member of the speaker{\textquoteright}s bureau for Astellas, Pfizer, and Merck. G.R.D. has received grant support from Fujisawa/Astellas, Merck, and Optimer. B.D. has received grant support from Astellas, Pfizer, Sch-ering, and Merck, is a consultant for Bio Alliance Pharma, and is a member of the speaker{\textquoteright}s bureau for Astellas, Schering, and Merck. M.E. has received grant support from Merck and Gilead and is a member of the speaker{\textquoteright}s bureau for Merck and Gilead. A.E.-I. has received grant supportfrom Pfizer and Schering Plough. J.A.F. has received grant support from Astellas and Roche, is a consultant for Gilead, Merck, Biogen-IDEC, Hoffman LaRoche, Athelas Primera, FDA/CBER–Xenotransplantation, and is a member of the speaker{\textquoteright}s bureau for the Immune Tolerance Network–National Institute of Allergy and Infectious Diseases–National Institutes of Health Transplantation Trials. R.F. has received research support from Cubicin and GlaxoSmthKline, is a consultant for Pfizer, Elan Pharmaceuticals, Abbott, and GlaxoSmth-Kline, and is a member of the speaker{\textquoteright}s bureau for Merck, Pfizer, and GlaxoSmthKline. G.F. has received research support from Astellas, Cubist, and Pfizer and is a member of the speaker{\textquoteright}s bureau for Astellas, Cubist, Pfizer, and Schering Plough. M. Ghannoum has received grant support from Astellas, Enzon, Indevus, Pfizer, Merck, Helix BioAlliance, Novartis, Anacor, Nex Med, Maruho, and Great Lakes Pharmaceuticals, is a consultant for Stiefel, Pfizer, Schering Plough, Novartis , and Enzon, and is a member of the speaker{\textquoteright}s bureau for Astellas, Merck, Pfizer, Schering Plough, and Enzon. M. Goldman has received research support from Pfizer and Glaxo, is a consultant for Gilead Sciences, Schering Plough, and Merck, and is a member of the speaker{\textquoteright}s bureau for Merck. J.N.G. has received research support from Pfizer and Sch-ering Plough. R.N.G. has received researchsupport from Acambis, Vaxgen, Dynport, Tibotec, Merck, Schering Plough, VirXsys, GlaxoSmthKline, Boer-inger-Ingelheim, Bristol Myers Squibb, and VA, is a consultant for Acambis, and is a member of the speaker{\textquoteright}s bureau for Schering Plough. P.O.G. has received research support from Astellas and Pfizer, is a consultant for Astellas and Merck, and is a member of the speaker{\textquoteright}s bureau for Astellas and Merck. S.H. has received research support from Pfizer, is a consultant for Astellas, Schering Plough, and Domantis, and is a member of the speaker{\textquoteright}s bureau for Astellas, Merck, Pfizer, Schering Plough, and Enzon. R.H. has received research support from Pfizer, is a consultant for ACE Biosciences, Astellas, Gilead Sciences, Merck, Pfizer, Schering Plough, and Zeneus, and is a member of the speaker{\textquoteright}s bureau for Gilead Sciences, Pfizer, and Schering Plough. J.W.H. has received research support from Astellas, Curagen, and Schering Plough, is a consultant for Astellas, Pfizer, Three Rivers, and Schering Plough, and is a member of the speaker{\textquoteright}s bureau for Astellas, Merck, and Pfizer. W.H. is associated with Astellas. D.R.H. has received grant support from Merck, Pfizer, and Schering Plough and is a member of the speaker{\textquoteright}s bureau for Merck and Pfizer. J.I.I. is a consultant for Enzon, Pfizer, and Schering Plough and is a member of the speaker{\textquoteright}s bureau for Astellas, En-zon, Pfizer, and Schering Plough. R.M.J. has received grant support from Merck, VaxGen, BioPort, and Chiron (Novartis). D.H.K. has received grant support from Pfizer, Wyeth, Merck, Astellas, and Hopira, is a consultant for Pfizer, Enzon, Cubist, Wyeth, Astellas, Lilly, Sanofi Av-entis, and GlaxoSmithKline, and is a member of the speaker{\textquoteright}s bureau for Pfizer, Cubist, Wyeth, Merck, Astellas, Lilly, Sanofi Aventis, and Glaxo. K.K. has received grant support from Merck and Schering Plough. D.P.K. has received grant support from Schering Plough, Pfizer, Astellas, Enzon, and Merck. R.L. has received grant support from Merck, Incyte Abbott, Boeringer Ingleheim, and Gilead Sciences. M.L. has received grant support from Astellas, Pfizer, Merck, Schering Plough, BioRad Laboratories, and Vicuron, is a consultant for Pfizer Canada, Astellas Canada, Merck Frosst Canada, and Schering Canada, and is a member of the speaker{\textquoteright}s bureau for Pfizer Canada, Astellas Canada, and Merck Frosst Canada. P.L. is a consultant for Gilead Sciences and a member of the speaker{\textquoteright}s bureau for Zeneus Pharma. J.M. has received grant support from Pfizer, Bio-Rad, and MSD, is a consultant for Astellas, Gilead Sciences, Funding Information: Nektar, Pfizer, MSD, and Schering Plough, and is a member of the speaker{\textquoteright}s bureau for Astellas, Gilead Sciences, Merck, Pfizer, Schering Plough, MSD, and Bio-Rad. G.M. has received grant support from Astellas and MGI and is a member of the speaker{\textquoteright}s bureau for Astellas, Merck, and Pfizer. M.R.M. is a member of the speaker{\textquoteright}s bureau for Schering Plough. M.M. has received grant support from Pfizer and Merck, is a consultant for Astellas, Enzon, and Pfizer, and is a member of the speaker{\textquoteright}s bureau for Astellas, Cubist, and En-zon. M.N. has received grant support from As-tellas, Enzon, Merck, and Schering Plough, is a consultant for Gilead Sciences, Pfizer, and Merck, and is a member of the speaker{\textquoteright}s bureau for Gilead Sciences, Merck, and Pfizer Major. F.C.O. has received grant support from Merck, MDS UK, Johnson & Johnson, Syngenta, and Italfarmaco, is a consultant for Bristol Myers Squibb, Gilead Sciences, Italfarmco, Johnson & Johnson, Merck, Oxford Glycosciences, Pfizer, Schering Plough, Syn-genta, Tibotec, and Vicuron, is a member of the speaker{\textquoteright}s bureau for Astellas, Gilead Sciences, Merck, Pfizer, and Schering Plough, and is a stockholder in Johnson & Johnson. T.P. has received grant support from Astellas, Enzon, Pfizer, Nektar, Merck, and Schering Plough, is a consultant for Astellas, Merck, Pfizer, Schering Plough, Affinium Pharmaceuticals, Basilea, Diversa, Eisai, Uriach, MediciNova, Microbia, Nektar, Rib-X Pharmaceuticals, Human Genome Sciences, and Coge-nesys, and is a member of the speaker{\textquoteright}s bureau for Astellas, Merck, Pfizer, and Schering Plough. R.R.R. has received grant support from Roche Laboratories. A.C.R. has received grant support from Merck, Cadence, and Optima, is a consultant for Pfizer and Astellas, and is a member of the speaker{\textquoteright}s bureau for Pfizer and Merck. J.L.R.T.. has received grant support from Pfizer, Merck, Schering Plough, and Gilead and is a member of the speaker{\textquoteright}s bureau for Gilead, Merck, Pfizer, and Schering Plough. C.R. has received grant support from Astellas, Johnson & Johnson, Pfizer, Wyeth, and Merck and is a consultant for Astellas, Bayer, Merck, Pfizer, and Wyeth. M.R. has received grant support from Pfizer, is a consultant for Astellas, Gilead Sciences, Pfizer, Shering Plough, Janssen, and Merck/MSD, and is a member of the speaker{\textquoteright}s bureau for Gilead, Merck, Pfizer, and Schering Plough. M.S. has received grant support from As-tellas, Enzon, Pfizer, and Merck and is a member of the speaker{\textquoteright}s bureau for Enzon and Pfizer. S.S. has received grant support from Astellas, Enzon, Merck, and AdvanDx, is a consultant for Pfizer, Astellas, Merck, and Enzon, is a member of the speaker{\textquoteright}s bureau for Pfizer, Roche, Merck, Enzon, and AdvanDx, and is a stockholder in Medonyx. N.S. is a consultant for Enzon and is a member of the speaker{\textquoteright}s bureau for Astellas, Pfizer, and Enzon. N.S. has received grant support from Sch- ering Plough and Enzon. W.J.S. has received grant support from Astellas and Merck and is a member of the speaker{\textquoteright}s bureau for Schering Plough, As-tellas, and Pfizer. Z.T. has received grant support from Abbott, Gilead Sciences, and Bristol Myers Squibb. C.V. has received grant support from Gil-ead Sciences and Wyeth, is a consultant for Pfizer, and is a member of the speaker{\textquoteright}s bureau for Gilead Sciences. M.A.V. is a member of the speaker{\textquoteright}s bureau for Gilead Sciences. J.L.W. is a consultant for BioRad and a stockholder in Miravista Diagnostics and MiraBella Technologies. J.R.W. has received grant support from Merck and Schering Plough, is a consultant for Merck, Nektar, Pfizer, and Sch-ering Plough, and is a member of the speaker{\textquoteright}s bureau for Merck, Pfizer, and Schering Plough. V.L.Y. has recieved grant support from Pfizer and OrthoMcNeil. T.Z. has received grant support from Merck, Pfizer, and Elan and is a consultant for Enzon and Zeneus. All other authors: no conflicts.",

year = "2006",

month = oct,

day = "15",

doi = "10.1086/509116",

language = "English (US)",

volume = "43",

pages = "1031--1039",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "8",

}

Anaissie, EJ, Segal, BH, Graybill, JR, Arndt, C, Perfect, JR, Kleinberg, M, Pappas, P, Benjamin, D, Rubin, R, Aberg, JA, Adderson, EE, Adler-Shohet, FC, Akan, H, Akova, M, Almyroudis, NG, Alexander, BD, Andes, D, Arrieta, A, Baddley, JW, Barron, MA, Belzberg, H, Boucher, HW, Boyce, TG, Casadevall, A, Chandrasekar, PH, Cleary, JD, Cordonnier, C, Cornely, OA, Cuenca-Estrella, M, Daly, JS, Daoura, N, Denning, DW, DePauw, B, De Repentigny, L, Dignani, MC, Dismukes, WE, Donnelly, JP, Donowitz, GR, Dupont, B, Drusano, G, Ellis, M, Espinel-Ingroff, A, Fishman, JA, Fleming, R, Forrest, G, Ghannoum, M, Goldman, M, Grazziutti, M, Greene, JH, Greenberg, RN, Gubbins, PO, Hadley, S, Herbrecht, R, Hiemenz, JW, Hope, W, Hospenthal, DR, Husain, S, Ito, JI, Jacobson, RM, Johnson, M, Keating, MR, Kett, DH, Knapp, K, Kontoyiannis, DP, Krcmery, VC, Larsen, R, Laverdiere, M, Ljungman, P, Lortholary, O, Maertens, J, Marriott, D, Mattiuzzi, G, McGinnis, MR, Morris, M, Nucci, M, Odds, FC, Pankey, GA, Patterson, T, Pfaller, M, Razonable, RR, Reboli, AC, Rinaldi, MG, Roberts, GD, Rodriguez Tudela, JL, Rotstein, C, Ruhnke, M, Schuster, M, Shoham, S, Sia, IG, Siebel, N, Silviera, F, Singh, N, Sobel, J, Solomkin, JS, Sorrell, TC, Steinbach, WJ, Temesgen, Z, Tortorano, A, Vartivarian, S, Verweij, P, Viscoli, C, Viviani, MA, Walker, RC, Wheat, JL, Wiley, J, Williamson, P, Wingard, JR, Yu, VL & Zaoutis, T 2006, 'Clinical research in the lay press: Irresponsible journalism raises a huge dose of doubt', Clinical Infectious Diseases, vol. 43, no. 8, pp. 1031-1039. https://doi.org/10.1086/509116

TY - JOUR

T1 - Clinical research in the lay press

T2 - Irresponsible journalism raises a huge dose of doubt

AU - Anaissie, Elias J.

AU - Segal, Brahm H.

AU - Graybill, John R.

AU - Arndt, Carola

AU - Perfect, John R.

AU - Kleinberg, Michael

AU - Pappas, Peter

AU - Benjamin, Danny

AU - Rubin, Robert

AU - Aberg, Judith A.

AU - Adderson, Elisabeth E.

AU - Adler-Shohet, Felice C.

AU - Akan, Hamdi

AU - Akova, Murat

AU - Almyroudis, Nikolaos G.

AU - Alexander, Barbara D.

AU - Andes, David

AU - Arrieta, Antonio

AU - Baddley, John W.

AU - Barron, Michelle A.

AU - Belzberg, Howard

AU - Boucher, Helen W.

AU - Boyce, Thomas G.

AU - Casadevall, Arturo

AU - Chandrasekar, P. H.

AU - Cleary, John D.

AU - Cordonnier, Catherine

AU - Cornely, Oliver A.

AU - Cuenca-Estrella, Manuel

AU - Daly, Jennifer S.

AU - Daoura, Nicholas

AU - Denning, David W.

AU - DePauw, Ben

AU - De Repentigny, Louis

AU - Dignani, Maria Cecilia

AU - Dismukes, William E.

AU - Donnelly, J. Peter

AU - Donowitz, Gerald R.

AU - Dupont, Bertrand

AU - Drusano, George

AU - Ellis, Michael

AU - Espinel-Ingroff, Ana

AU - Fishman, Jay A.

AU - Fleming, Rhonda

AU - Forrest, Graeme

AU - Ghannoum, Mahmoud

AU - Goldman, Mitchell

AU - Grazziutti, Monica

AU - Greene, John H.

AU - Greenberg, Richard N.

AU - Gubbins, Paul O.

AU - Hadley, Susan

AU - Herbrecht, Raoul

AU - Hiemenz, John W.

AU - Hope, William

AU - Hospenthal, Durane R.

AU - Husain, Shahid

AU - Ito, James I.

AU - Jacobson, Robert M.

AU - Johnson, Melissa

AU - Keating, Michael R.

AU - Kett, Daniel H.

AU - Knapp, Katherine

AU - Kontoyiannis, Dimitrios P.

AU - Krcmery, Vladimir C.

AU - Larsen, Robert

AU - Laverdiere, Michel

AU - Ljungman, Per

AU - Lortholary, O.

AU - Maertens, Johan

AU - Marriott, Debbie

AU - Mattiuzzi, Gloria

AU - McGinnis, Michael R.

AU - Morris, Michele

AU - Nucci, Marcio

AU - Odds, Frank C.

AU - Pankey, George A.

AU - Patterson, Thomas

AU - Pfaller, Mike

AU - Razonable, Raymond R.

AU - Reboli, Annette C.

AU - Rinaldi, Michael G.

AU - Roberts, Glenn D.

AU - Rodriguez Tudela, Juan Luis

AU - Rotstein, Coleman

AU - Ruhnke, Markus

AU - Schuster, Mindy

AU - Shoham, Shmuel

AU - Sia, Irene G.

AU - Siebel, Nita

AU - Silviera, Fernanda

AU - Singh, Nina

AU - Sobel, Jack

AU - Solomkin, Joseph S.

AU - Sorrell, Tania C.

AU - Steinbach, William J.

AU - Temesgen, Zelalem

AU - Tortorano, Annamaria

AU - Vartivarian, Shahe

AU - Verweij, Paul

AU - Viscoli, Claudio

AU - Viviani, Maria Anna

AU - Walker, Randall C.

AU - Wheat, Joseph L.

AU - Wiley, Joseph

AU - Williamson, Peter

AU - Wingard, John R.

AU - Yu, Victor L.

AU - Zaoutis, Theoklis

N1 - Funding Information: ceived grant support from Astellas, Curagen, En-zon, Nuvelo, Orthobiotech, and Pfizer, is a consultant for Astellas, Gilead Sciences, Merck, Pfizer, and Schering Plough, and is a member of the speaker’s bureau for Astellas, Gilead Sciences, Merck, Pfizer, and Schering Plough. B.H.S. has received grant support from Astellas, is a consultant for Enzon and Schering Plough, and is a member of the speaker’s bureau for Merck and Pfizer. J.R.G. has received grant support from Aro-nex, Vicuron, Pfizer, Schering, Fujisawa, Astellas, F2G, Merck, and Indevus, is a consultant for Aro-nex, Vicuron, Pfizer, Schering, Fujisawa, Astellas, F2G, Merck, Indevus, Abbott, and Glaxo-SmithKline, and is a member of the speaker’s bureau for Pfizer, Schering, and F2G. C.A. is a stockholder in Merck. J.R.P. has received grant support from Merck, Enzon, Astellas, Schering Plough, and Pfizer and is a consultant for Merck, Enzon, As-tellas, Schering Plough, and Pfizer. M.K. has received grant support from Pfizer and is a member of the speaker’s bureau for Pfizer and Enzon. D.B. has received grant support from Astellas, Med-Immune, Pediatrix, Rocketasher Research, Astra Zeneca, Johnson & Johnson, Pfizer, and Vicuron. J.A.A. has received grant support from Bristol My-ers Squibb, Gilead, Abbott, Roche, Berlex Labs, Merck, GlaxoSmithKline, and Tibotec and is a consultant for Bristol Myers Squibb, Gilead, Abbott, GlaxoSmithKline, and Boehringer Ingelheim. B.D.A. has received grant support from Astellas and Enzon, is a consultant for Astellas, Pfizer, Sch-ering Plough, Enzon, Bristol Myers Squibb/Eisai Medical Research, Cubicin, Merck, Novartis,Phar- macia, Roche, Vircuron, and Viropharma, and is a member of the speaker’s bureau for Astellas, Pfizer, Schering Plough, and OrthoBiotec. D.A. has received grant support from Astellas, Pfizer, En-zon, Schering, GlaxoSmithKline, and Merck, is a consultant for Pfizer, Schering Plough, and Merck, and is a member of the speaker’s bureau for Pfizer and Merck. J.W.B. has received grant support from Merck and Astellas, is a consultant for Merck, and is a member of the speaker’s bureau for Enzon, Merck, and Pfizer. M.A.B. has received grant support from Astellas, Cubist, Genzyme, and Merck, is a consultant for Astellas, Abbott, Pfizer, Merck, and Schering Plough, and is a member of the speaker’s bureau for Astellas, Abbott, Pfizer, Merck, and Schering Plough. H.W.B. is a consultant for Cubist Pharmaceuticals, Pfizer, As-preva, Aspreva Pharmaceuticals, and Schering Plough, is a member of the speaker’s bureau for Cubist Pharmaceuticals, Pfizer, Aspreva, Aspreva Pharmaceuticals, and Schering Plough, and is a stock holder in Cubist. T.G.B. is a member of the speaker’s bureau for Abbott, MedImmune, Pfizer, and Sanofi-Pasteur. A.C. has received grant support from Pfizer and Energy Dynamics and is a consultant for Pfizer, Merck, Wyeth, Bioveris, and Energy Dynamics. O.A.C. has received grant support from Astellas, Basilea, Gilead, Pfizer, Merck, Schering Plough, and Vicuron, is a consultant for Astellas, Basilea, Gilead, Pfizer, Merck, Nektar, and Schering Plough, and is a member of the speaker’s bureau for Astellas, Gilead, Merck, and Schering Plough. M.C.-E. has received grant support from Pfizer, Merck, Schering Plough, and Gilead and is a member of the speaker’s bureau for Gilead, Merck, Pfizer, and Schering Plough. J.S.D. has received grant support from Merck and Schering Plough. L.d.R. has received grant support from the Canadian Institute of Health. M.C.D. is a member of the speaker’s bureau for Pfizer. W.E.D. has received grant support from Merck and Astellas, is a consultant for Astellas and Pfizer, and is a member of the speaker’s bureau for Astellas, Pfizer, and Merck. G.R.D. has received grant support from Fujisawa/Astellas, Merck, and Optimer. B.D. has received grant support from Astellas, Pfizer, Sch-ering, and Merck, is a consultant for Bio Alliance Pharma, and is a member of the speaker’s bureau for Astellas, Schering, and Merck. M.E. has received grant support from Merck and Gilead and is a member of the speaker’s bureau for Merck and Gilead. A.E.-I. has received grant supportfrom Pfizer and Schering Plough. J.A.F. has received grant support from Astellas and Roche, is a consultant for Gilead, Merck, Biogen-IDEC, Hoffman LaRoche, Athelas Primera, FDA/CBER–Xenotransplantation, and is a member of the speaker’s bureau for the Immune Tolerance Network–National Institute of Allergy and Infectious Diseases–National Institutes of Health Transplantation Trials. R.F. has received research support from Cubicin and GlaxoSmthKline, is a consultant for Pfizer, Elan Pharmaceuticals, Abbott, and GlaxoSmth-Kline, and is a member of the speaker’s bureau for Merck, Pfizer, and GlaxoSmthKline. G.F. has received research support from Astellas, Cubist, and Pfizer and is a member of the speaker’s bureau for Astellas, Cubist, Pfizer, and Schering Plough. M. Ghannoum has received grant support from Astellas, Enzon, Indevus, Pfizer, Merck, Helix BioAlliance, Novartis, Anacor, Nex Med, Maruho, and Great Lakes Pharmaceuticals, is a consultant for Stiefel, Pfizer, Schering Plough, Novartis , and Enzon, and is a member of the speaker’s bureau for Astellas, Merck, Pfizer, Schering Plough, and Enzon. M. Goldman has received research support from Pfizer and Glaxo, is a consultant for Gilead Sciences, Schering Plough, and Merck, and is a member of the speaker’s bureau for Merck. J.N.G. has received research support from Pfizer and Sch-ering Plough. R.N.G. has received researchsupport from Acambis, Vaxgen, Dynport, Tibotec, Merck, Schering Plough, VirXsys, GlaxoSmthKline, Boer-inger-Ingelheim, Bristol Myers Squibb, and VA, is a consultant for Acambis, and is a member of the speaker’s bureau for Schering Plough. P.O.G. has received research support from Astellas and Pfizer, is a consultant for Astellas and Merck, and is a member of the speaker’s bureau for Astellas and Merck. S.H. has received research support from Pfizer, is a consultant for Astellas, Schering Plough, and Domantis, and is a member of the speaker’s bureau for Astellas, Merck, Pfizer, Schering Plough, and Enzon. R.H. has received research support from Pfizer, is a consultant for ACE Biosciences, Astellas, Gilead Sciences, Merck, Pfizer, Schering Plough, and Zeneus, and is a member of the speaker’s bureau for Gilead Sciences, Pfizer, and Schering Plough. J.W.H. has received research support from Astellas, Curagen, and Schering Plough, is a consultant for Astellas, Pfizer, Three Rivers, and Schering Plough, and is a member of the speaker’s bureau for Astellas, Merck, and Pfizer. W.H. is associated with Astellas. D.R.H. has received grant support from Merck, Pfizer, and Schering Plough and is a member of the speaker’s bureau for Merck and Pfizer. J.I.I. is a consultant for Enzon, Pfizer, and Schering Plough and is a member of the speaker’s bureau for Astellas, En-zon, Pfizer, and Schering Plough. R.M.J. has received grant support from Merck, VaxGen, BioPort, and Chiron (Novartis). D.H.K. has received grant support from Pfizer, Wyeth, Merck, Astellas, and Hopira, is a consultant for Pfizer, Enzon, Cubist, Wyeth, Astellas, Lilly, Sanofi Av-entis, and GlaxoSmithKline, and is a member of the speaker’s bureau for Pfizer, Cubist, Wyeth, Merck, Astellas, Lilly, Sanofi Aventis, and Glaxo. K.K. has received grant support from Merck and Schering Plough. D.P.K. has received grant support from Schering Plough, Pfizer, Astellas, Enzon, and Merck. R.L. has received grant support from Merck, Incyte Abbott, Boeringer Ingleheim, and Gilead Sciences. M.L. has received grant support from Astellas, Pfizer, Merck, Schering Plough, BioRad Laboratories, and Vicuron, is a consultant for Pfizer Canada, Astellas Canada, Merck Frosst Canada, and Schering Canada, and is a member of the speaker’s bureau for Pfizer Canada, Astellas Canada, and Merck Frosst Canada. P.L. is a consultant for Gilead Sciences and a member of the speaker’s bureau for Zeneus Pharma. J.M. has received grant support from Pfizer, Bio-Rad, and MSD, is a consultant for Astellas, Gilead Sciences, Funding Information: Nektar, Pfizer, MSD, and Schering Plough, and is a member of the speaker’s bureau for Astellas, Gilead Sciences, Merck, Pfizer, Schering Plough, MSD, and Bio-Rad. G.M. has received grant support from Astellas and MGI and is a member of the speaker’s bureau for Astellas, Merck, and Pfizer. M.R.M. is a member of the speaker’s bureau for Schering Plough. M.M. has received grant support from Pfizer and Merck, is a consultant for Astellas, Enzon, and Pfizer, and is a member of the speaker’s bureau for Astellas, Cubist, and En-zon. M.N. has received grant support from As-tellas, Enzon, Merck, and Schering Plough, is a consultant for Gilead Sciences, Pfizer, and Merck, and is a member of the speaker’s bureau for Gilead Sciences, Merck, and Pfizer Major. F.C.O. has received grant support from Merck, MDS UK, Johnson & Johnson, Syngenta, and Italfarmaco, is a consultant for Bristol Myers Squibb, Gilead Sciences, Italfarmco, Johnson & Johnson, Merck, Oxford Glycosciences, Pfizer, Schering Plough, Syn-genta, Tibotec, and Vicuron, is a member of the speaker’s bureau for Astellas, Gilead Sciences, Merck, Pfizer, and Schering Plough, and is a stockholder in Johnson & Johnson. T.P. has received grant support from Astellas, Enzon, Pfizer, Nektar, Merck, and Schering Plough, is a consultant for Astellas, Merck, Pfizer, Schering Plough, Affinium Pharmaceuticals, Basilea, Diversa, Eisai, Uriach, MediciNova, Microbia, Nektar, Rib-X Pharmaceuticals, Human Genome Sciences, and Coge-nesys, and is a member of the speaker’s bureau for Astellas, Merck, Pfizer, and Schering Plough. R.R.R. has received grant support from Roche Laboratories. A.C.R. has received grant support from Merck, Cadence, and Optima, is a consultant for Pfizer and Astellas, and is a member of the speaker’s bureau for Pfizer and Merck. J.L.R.T.. has received grant support from Pfizer, Merck, Schering Plough, and Gilead and is a member of the speaker’s bureau for Gilead, Merck, Pfizer, and Schering Plough. C.R. has received grant support from Astellas, Johnson & Johnson, Pfizer, Wyeth, and Merck and is a consultant for Astellas, Bayer, Merck, Pfizer, and Wyeth. M.R. has received grant support from Pfizer, is a consultant for Astellas, Gilead Sciences, Pfizer, Shering Plough, Janssen, and Merck/MSD, and is a member of the speaker’s bureau for Gilead, Merck, Pfizer, and Schering Plough. M.S. has received grant support from As-tellas, Enzon, Pfizer, and Merck and is a member of the speaker’s bureau for Enzon and Pfizer. S.S. has received grant support from Astellas, Enzon, Merck, and AdvanDx, is a consultant for Pfizer, Astellas, Merck, and Enzon, is a member of the speaker’s bureau for Pfizer, Roche, Merck, Enzon, and AdvanDx, and is a stockholder in Medonyx. N.S. is a consultant for Enzon and is a member of the speaker’s bureau for Astellas, Pfizer, and Enzon. N.S. has received grant support from Sch- ering Plough and Enzon. W.J.S. has received grant support from Astellas and Merck and is a member of the speaker’s bureau for Schering Plough, As-tellas, and Pfizer. Z.T. has received grant support from Abbott, Gilead Sciences, and Bristol Myers Squibb. C.V. has received grant support from Gil-ead Sciences and Wyeth, is a consultant for Pfizer, and is a member of the speaker’s bureau for Gilead Sciences. M.A.V. is a member of the speaker’s bureau for Gilead Sciences. J.L.W. is a consultant for BioRad and a stockholder in Miravista Diagnostics and MiraBella Technologies. J.R.W. has received grant support from Merck and Schering Plough, is a consultant for Merck, Nektar, Pfizer, and Sch-ering Plough, and is a member of the speaker’s bureau for Merck, Pfizer, and Schering Plough. V.L.Y. has recieved grant support from Pfizer and OrthoMcNeil. T.Z. has received grant support from Merck, Pfizer, and Elan and is a consultant for Enzon and Zeneus. All other authors: no conflicts.

PY - 2006/10/15

Y1 - 2006/10/15

UR - http://www.scopus.com/inward/record.url?scp=33750357776&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750357776&partnerID=8YFLogxK

U2 - 10.1086/509116

DO - 10.1086/509116

M3 - Review article

C2 - 16983616

AN - SCOPUS:33750357776

SN - 1058-4838

VL - 43

SP - 1031

EP - 1039

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 8

ER -

Clinical research in the lay press: Irresponsible journalism raises a huge dose of doubt

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