TY - JOUR
T1 - Clinical and biochemical aspects of depressive disorders
T2 - I. Introduction, classification, and research techniques
AU - Caldecott‐Hazard, Sally
AU - Guze, Barry H.
AU - Kling, Mitchel A.
AU - Kling, Arthur
AU - Baxter, Lewis R.
PY - 1991/7
Y1 - 1991/7
N2 - The present review focuses on recent data from clinical and animal research concerning the biochemical bases of depressive disorders, diagnosis, and treatment. In addition to integrating these data, problems and future directions in this research are discussed. The review is presented in three parts. This study, Part I, describes diagnostic classification schemes for depressive disorders, some epidemiological and biological correlates of the classifications, and research techniques for investigating depressive disorders. Research techniques include animal models, human biochemical techniques, and Postron Emission Tomography. In a future issue, Part II will discuss various transmitter/receptor theories of depressive disorders, e.g., noradrenergic, serotonergic, cholinergic, and dopaminergic, GABAergic, and peptidergic theories. Also in a future issue, Part III will discuss treatments for depression and some of the controversies in the field.
AB - The present review focuses on recent data from clinical and animal research concerning the biochemical bases of depressive disorders, diagnosis, and treatment. In addition to integrating these data, problems and future directions in this research are discussed. The review is presented in three parts. This study, Part I, describes diagnostic classification schemes for depressive disorders, some epidemiological and biological correlates of the classifications, and research techniques for investigating depressive disorders. Research techniques include animal models, human biochemical techniques, and Postron Emission Tomography. In a future issue, Part II will discuss various transmitter/receptor theories of depressive disorders, e.g., noradrenergic, serotonergic, cholinergic, and dopaminergic, GABAergic, and peptidergic theories. Also in a future issue, Part III will discuss treatments for depression and some of the controversies in the field.
UR - http://www.scopus.com/inward/record.url?scp=0026018294&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026018294&partnerID=8YFLogxK
U2 - 10.1002/syn.890080306
DO - 10.1002/syn.890080306
M3 - Article
C2 - 1948669
AN - SCOPUS:0026018294
SN - 0887-4476
VL - 8
SP - 185
EP - 211
JO - Synapse
JF - Synapse
IS - 3
ER -