Chondrocyte metabolism as affected by vitamin A

N. S. Vasan, J. W. Lash

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Chondrocytes from 13-day-old embryonic chick sterna were cultured for 6 days in the presence of vitamin A (10 I.U./ml). Vitamin A treated chondrocytes became flattened and stellate within the first 24 hours of culture. After 6 days of culture, the treated cells contained 59% less DNA than the untreated controls. Sulfated glycosaminoglycan synthesis was inhibited 84%, and a greater percentage of GAG was secreted into the medium (90%) than in control cultures (78%). Vitamin A inhibited cell proliferation, and to varying degrees, RNA and protein synthesis, and these effects are dose dependent.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalCalcified Tissue Research
Issue number1
StatePublished - Dec 1975
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Endocrinology


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