Challenges and solutions in topical ocular drug-delivery systems

Maryam Ali, Mark Byrne

    Research output: Contribution to journalReview articlepeer-review

    37 Scopus citations

    Abstract

    Vision significantly affects quality of life and the treatment of ocular disease poses a number of unique challenges. This review presents the major challenges faced during topical ocular drug administration and highlights strategies used to overcome the natural transport barriers of the eye. The circulation of tear fluid and aqueous humor decrease the residence time of topically delivered drugs, while ocular barriers in the corneal and conjuctival epithelia and the retinal pigment epithelium limit transport. Successful treatment strategies increase the residence time of drugs in the eye and/or enhance the ability of the drug to penetrate the ocular barriers and reach the target tissue. In this review, we discuss several drug-delivery strategies that have achieved clinical success or demonstrate high potential. We also draw attention to a number of excellent reviews that explore various ocular drug-delivery techniques in depth. Finally, we highlight cutting-edge drug-delivery technologies that improve the efficacy of current drug-delivery methods or use proven techniques to deliver novel therapeutics.

    Original languageEnglish (US)
    Pages (from-to)145-161
    Number of pages17
    JournalExpert Review of Clinical Pharmacology
    Volume1
    Issue number1
    DOIs
    StatePublished - Jan 25 2008

    All Science Journal Classification (ASJC) codes

    • Pharmacology, Toxicology and Pharmaceutics(all)
    • Pharmacology (medical)

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