@article{f9c70d34273e4cad99f587e27f039b7f,
title = "Cell encapsulation in gelatin bioink impairs 3D bioprinting resolution",
abstract = "Recent advances in three-dimensional (3D) bioprinting technologies have enabled precise patterning of cellular components along with biomimetic constructs for tissue engineering and regenerative medicine. The viscoelasticity of bioinks regulate printability and the smallest feature size in 3D bioprinted constructs. The impact of cellular components is typically neglected when choosing 3D bioprinting parameters. In this short communication, we quantified the effect of cell densities on the printability of hydrogel bioinks. Unexpectedly, our results show that encapsulated cells reduced the steady shear viscosity of gelatin-based bioinks by approximately 50% and the minimum force for onset of flow by approximately 30%. These results may justify the lower spatial resolution in 3D bioprinted cell-laden hydrogels.",
author = "Rachel Schwartz and Matthew Malpica and Thompson, {Gary L.} and Miri, {Amir K.}",
note = "Funding Information: The authors gratefully acknowledge funding from Rowan University. We thank Dr. Reza Avaz (University of Texas-Austin) for his comments and feedback. Dr. Miri also acknowledges the financial support from New Jersey Health Foundation . We thank Dr. Mark Byrne (Department of Biomedical Engineering, Rowan University) for sharing the rheometer for our experiments. We also acknowledge Shola Onissema-Karimu (Department of Biomedical Engineering, Rowan University) for her assistance with our data analysis for supplementary figures. Appendix A Funding Information: The authors gratefully acknowledge funding from Rowan University. We thank Dr. Reza Avaz (University of Texas-Austin) for his comments and feedback. Dr. Miri also acknowledges the financial support from New Jersey Health Foundation. We thank Dr. Mark Byrne (Department of Biomedical Engineering, Rowan University) for sharing the rheometer for our experiments. We also acknowledge Shola Onissema-Karimu (Department of Biomedical Engineering, Rowan University) for her assistance with our data analysis for supplementary figures. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2020",
month = mar,
doi = "10.1016/j.jmbbm.2019.103524",
language = "English (US)",
volume = "103",
journal = "Journal of the Mechanical Behavior of Biomedical Materials",
issn = "1751-6161",
publisher = "Elsevier BV",
}