Cell attachment and proliferation on hydroxyapatite and ion substituted hydroxyapatites

M. Wei; D. Vellinga; D. Leavesley; J. Evans; Z. Upton

Cell attachment and proliferation on hydroxyapatite and ion substituted hydroxyapatites

M. Wei
, D. Vellinga
, D. Leavesley
, J. Evans
, Z. Upton

Research output: Contribution to journal › Conference article › peer-review

Abstract

Hydroxyapatite (HA), partially fluoride substituted hydroxyapatite (fHA), and fluorapatite (FA) were synthesized in-house and characterised. Cell attachment and proliferation on polystyrene, titanium, HA, fHA and FA were investigated. It was found that fHA was a promising biomaterial. This material supports osteoblast cell attachment equivalent to that observed with polystyrene (plastic tissue culture well), titanium (a widely used metal implant material), HA and FA. However, it is significantly superior to these materials in inducing proliferation of the human osteoblast cell line. The cell proliferation rate on fHA is more than double the rate of the remaining materials, including HA, a widely used biomaterial. fHA may thus be a potential candidate biomaterial for biomedical applications.

Original language	English (US)
Pages (from-to)	671-674
Number of pages	4
Journal	Key Engineering Materials
Volume	240-242
State	Published - 2003
Externally published	Yes
Event	Proceedings of the 15th International Symposium on Ceramics in Medicine; The Annual Meeting of the International Society for Ceramics in Medicine - Sydney, NSW, Australia Duration: Dec 4 2002 → Dec 8 2002

All Science Journal Classification (ASJC) codes

General Materials Science
Mechanics of Materials
Mechanical Engineering

Cite this

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title = "Cell attachment and proliferation on hydroxyapatite and ion substituted hydroxyapatites",

abstract = "Hydroxyapatite (HA), partially fluoride substituted hydroxyapatite (fHA), and fluorapatite (FA) were synthesized in-house and characterised. Cell attachment and proliferation on polystyrene, titanium, HA, fHA and FA were investigated. It was found that fHA was a promising biomaterial. This material supports osteoblast cell attachment equivalent to that observed with polystyrene (plastic tissue culture well), titanium (a widely used metal implant material), HA and FA. However, it is significantly superior to these materials in inducing proliferation of the human osteoblast cell line. The cell proliferation rate on fHA is more than double the rate of the remaining materials, including HA, a widely used biomaterial. fHA may thus be a potential candidate biomaterial for biomedical applications.",

author = "M. Wei and D. Vellinga and D. Leavesley and J. Evans and Z. Upton",

year = "2003",

language = "English (US)",

volume = "240-242",

pages = "671--674",

journal = "Key Engineering Materials",

issn = "1013-9826",

publisher = "Trans Tech Publications Ltd",

note = "Proceedings of the 15th International Symposium on Ceramics in Medicine; The Annual Meeting of the International Society for Ceramics in Medicine ; Conference date: 04-12-2002 Through 08-12-2002",

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TY - JOUR

T1 - Cell attachment and proliferation on hydroxyapatite and ion substituted hydroxyapatites

AU - Wei, M.

AU - Vellinga, D.

AU - Leavesley, D.

AU - Evans, J.

AU - Upton, Z.

PY - 2003

Y1 - 2003

N2 - Hydroxyapatite (HA), partially fluoride substituted hydroxyapatite (fHA), and fluorapatite (FA) were synthesized in-house and characterised. Cell attachment and proliferation on polystyrene, titanium, HA, fHA and FA were investigated. It was found that fHA was a promising biomaterial. This material supports osteoblast cell attachment equivalent to that observed with polystyrene (plastic tissue culture well), titanium (a widely used metal implant material), HA and FA. However, it is significantly superior to these materials in inducing proliferation of the human osteoblast cell line. The cell proliferation rate on fHA is more than double the rate of the remaining materials, including HA, a widely used biomaterial. fHA may thus be a potential candidate biomaterial for biomedical applications.

AB - Hydroxyapatite (HA), partially fluoride substituted hydroxyapatite (fHA), and fluorapatite (FA) were synthesized in-house and characterised. Cell attachment and proliferation on polystyrene, titanium, HA, fHA and FA were investigated. It was found that fHA was a promising biomaterial. This material supports osteoblast cell attachment equivalent to that observed with polystyrene (plastic tissue culture well), titanium (a widely used metal implant material), HA and FA. However, it is significantly superior to these materials in inducing proliferation of the human osteoblast cell line. The cell proliferation rate on fHA is more than double the rate of the remaining materials, including HA, a widely used biomaterial. fHA may thus be a potential candidate biomaterial for biomedical applications.

UR - https://www.scopus.com/pages/publications/17444437504

UR - https://www.scopus.com/pages/publications/17444437504#tab=citedBy

M3 - Conference article

AN - SCOPUS:17444437504

SN - 1013-9826

VL - 240-242

SP - 671

EP - 674

JO - Key Engineering Materials

JF - Key Engineering Materials

T2 - Proceedings of the 15th International Symposium on Ceramics in Medicine; The Annual Meeting of the International Society for Ceramics in Medicine

Y2 - 4 December 2002 through 8 December 2002

ER -

Cell attachment and proliferation on hydroxyapatite and ion substituted hydroxyapatites

Abstract

All Science Journal Classification (ASJC) codes

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