Catalytic square-wave voltammetric detection of DNA with reversible metallopolymer-coated electrodes

Amos Mugweru, James F. Rusling

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Pyrolytic graphite electrodes with adsorbed poly(4-vinylpyridine) (PVP) with attached Ru(bpy)22+ gave reversible voltammetry, facilitating reusable DNA sensors. These electrodes gave catalytic voltammetric responses to poly(guanylic) acid and DNA at about 0.75 V vs SCE caused by catalytic oxidation of guanine moieties in these polynucleotides. ss-DNA gave twice the square-wave voltammetric catalytic current compared to an equivalent amount of ds-DNA, suggesting that the [Ru(bpy)2-PVP]2+ polymer may be useful for detection of DNA hybridization and damage.

Original languageEnglish (US)
Pages (from-to)406-409
Number of pages4
JournalElectrochemistry Communications
Volume3
Issue number8
DOIs
StatePublished - Aug 15 2001

All Science Journal Classification (ASJC) codes

  • Electrochemistry

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