TY - JOUR
T1 - Carotenoids in cancer chemoprevention
AU - Nishino, Hoyoku
AU - Murakoshi, Michiaki
AU - Ii, Tsunehiro
AU - Takemura, Manabu
AU - Kuchide, Masashi
AU - Kanazawa, Motohiro
AU - Yang Mou, Xiao
AU - Wada, Saeri
AU - Masuda, Mitsuharu
AU - Ohsaka, Yasuhito
AU - Yogosawa, Shingo
AU - Satomi, Yoshiko
AU - Jinno, Kenji
N1 - Funding Information:
This work was supported in part by grants from the Program for Promotion of Basic Research Activities for Innovative Biosciences (ProBRAIN), the Ministry of Agriculture, Forestry, and Fisheries, the Ministry of Health and Welfare, the Ministry of Education, Science and Culture, and Institute of Free Radical Control (IFRC), Japan. The study was carried out in collaboration with research groups of Kyoto Prefectural University of Medicine, Akita University College of Allied Medical Science, Kyoto Pharmaceutical University, Food Research Institute, Fruit Tree Research Station, National Cancer Center Research Institute, Shikoku Cancer Center, Lion Co., Dainippon Ink & Chemicals, Inc., Kagome Co., Kirin Brewery Co., Koyo Mercantile Co., Japan, Dr. Frederick Khachik, Department of Chemistry and Biochemistry, University of Maryland, USA, and Dr. Zohar Nir, LycoRed Natural Products Industries, Ltd., Israel. Authors are grateful to Dr. Takashi Sugimura, Emeritus President, National Cancer Center, Japan, for his kind encouragement during this study.
PY - 2002
Y1 - 2002
N2 - Various natural carotenoids, besides β-carotene, were proven to have anticarcinogenic activity, and some of them showed more potent activity than β-carotene. Thus, these carotenoids (α-carotene, lutein, zeaxanthin, lycopene, β-cryptoxanthin, fucoxanthin, astaxanthin, capsanthin, crocetin and phytoene), as well as β-carotene, may be useful for cancer prevention. In the case of phytoene, the concept of 'bio-chemoprevention', which means biotechnology-assisted method for cancer chemoprevention, may be applicable. In fact, establishment of mammalian cells producing phytoene was succeeded by the introduction of crtB gene, which encodes phytoene synthase, and these cells were proven to acquire the resistance against carcinogenesis. Antioxidative phytoene-containing animal foods may be classified as a novel type of functional food, which has the preventive activity against carcinogenesis, as well as the ability to reduce the accumulation of oxidative damages, which are hazardous for human health.
AB - Various natural carotenoids, besides β-carotene, were proven to have anticarcinogenic activity, and some of them showed more potent activity than β-carotene. Thus, these carotenoids (α-carotene, lutein, zeaxanthin, lycopene, β-cryptoxanthin, fucoxanthin, astaxanthin, capsanthin, crocetin and phytoene), as well as β-carotene, may be useful for cancer prevention. In the case of phytoene, the concept of 'bio-chemoprevention', which means biotechnology-assisted method for cancer chemoprevention, may be applicable. In fact, establishment of mammalian cells producing phytoene was succeeded by the introduction of crtB gene, which encodes phytoene synthase, and these cells were proven to acquire the resistance against carcinogenesis. Antioxidative phytoene-containing animal foods may be classified as a novel type of functional food, which has the preventive activity against carcinogenesis, as well as the ability to reduce the accumulation of oxidative damages, which are hazardous for human health.
UR - http://www.scopus.com/inward/record.url?scp=12244295498&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12244295498&partnerID=8YFLogxK
U2 - 10.1023/A:1021206826750
DO - 10.1023/A:1021206826750
M3 - Review article
C2 - 12549764
AN - SCOPUS:12244295498
SN - 0167-7659
VL - 21
SP - 257
EP - 264
JO - Cancer and Metastasis Reviews
JF - Cancer and Metastasis Reviews
IS - 3-4
ER -