Cardiac inositol 1,4,5-trisphosphate receptors

M. Iveth Garcia, Darren Boehning

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Calcium is a second messenger that regulates almost all cellular functions. In cardiomyocytes, calcium plays an integral role in many functions including muscle contraction, gene expression, and cell death. Inositol 1,4,5-trisphosphate receptors (IP3Rs) are a family of calcium channels that are ubiquitously expressed in all tissues. In the heart, IP3Rs have been associated with regulation of cardiomyocyte function in response to a variety of neurohormonal agonists, including those implicated in cardiac disease. Notably, IP3R activity is thought to be essential for mediating the hypertrophic response to multiple stimuli including endothelin-1 and angiotensin II. In this review, we will explore the functional implications of IP3R activity in the heart in health and disease.

Original languageEnglish (US)
Pages (from-to)907-914
Number of pages8
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1864
Issue number6
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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