Cancer on fire: role of inflammation in prevention and treatment

Manoj K. Pandey, Max Von Suskil, Robert Chitren, Omar Al-Odat, Subash C. Jonnalagadda, Bharat B. Aggarwal

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

It has been established that chronic inflammation plays a critical role in chronic diseases including cancers. Inflammation regulates various steps of neoplasia and is crucial in the tumor microenvironment. In the tumor microenvironment, proinflammatory gene products mediate various undesirable pathological processes including apoptosis suppression, survival, proliferation, invasion, metastasis, and angiogenesis. Among these gene products are members of the tumor necrosis factor (TNF) superfamily, interleukins, chemokines, matrix metalloproteinases, vascular epithelial growth factor, cyclooxygenases. The nuclear factor-B (NF-B) regulates the expression of these gene products and is often overexpressed in the majority of cancers. Because various factors contribute in tumorigenesis, it is logical to consider “magic bullets” for cancer prevention and treatment. The nutraceuticals derived from dietary agents including fruits, vegetables, spices, and cereals, possess immense potential. The mammoth research suggests that antiinflammatory nutraceuticals that suppress a variety of gene products important in the tumor microenvironment should have potential in both the prevention and treatment of cancer. Importantly, these nutraceuticals are safe and affordable. The present chapter discusses the molecular targets of common nutraceuticals and their role in cancer prevention and treatment.

Original languageEnglish (US)
Title of host publicationCurrent Advances for Development of Functional Foods Modulating Inflammation and Oxidative Stress
PublisherElsevier
Pages605-626
Number of pages22
ISBN (Electronic)9780128234822
ISBN (Print)9780128225844
DOIs
StatePublished - Jan 1 2022

All Science Journal Classification (ASJC) codes

  • General Engineering
  • General Agricultural and Biological Sciences

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