TY - JOUR
T1 - Cancer chemoprevention by ginseng in mouse liver and other organs.
AU - Nishino, H.
AU - Tokuda, H.
AU - Ii, T.
AU - Takemura, M.
AU - Kuchide, M.
AU - Kanazawa, M.
AU - Mou, X. Y.
AU - Bu, P.
AU - Takayasu, J.
AU - Onozuka, M.
AU - Masuda, M.
AU - Satomi, Y.
AU - Konoshima, T.
AU - Kishi, N.
AU - Baba, M.
AU - Okada, Y.
AU - Okuyama, T.
PY - 2001/12
Y1 - 2001/12
N2 - Oral administration of red ginseng extracts (1% in diet for 40 weeks) resulted in the significant suppression of spontaneous liver tumor formation in C3H/He male mice. Average number of tumors per mouse in control group was 1.06, while that in red ginseng extracts-treated group was 0.33 (p<0.05). Incidence of liver tumor development was also lower in red ginseng extracts-treated group, although the difference from control group was not statistically significant. Anti-carcinogenic activity of white ginseng extracts, besides red ginseng extracts, was also investigated. In the present study, the administration of white ginseng extracts was proven to suppress tumor promoter-induced phenomena in vitro and in vivo. It is of interest that oral administration of the extracts of Ren-Shen-Yang- Rong-Tang, a white ginseng-containing Chinese medicinal prescription, resulted in the suppression of skin tumor promotion by 12-o-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated CD-1 mice. These results suggest the usefulness of ginseng in the field of cancer prevention.
AB - Oral administration of red ginseng extracts (1% in diet for 40 weeks) resulted in the significant suppression of spontaneous liver tumor formation in C3H/He male mice. Average number of tumors per mouse in control group was 1.06, while that in red ginseng extracts-treated group was 0.33 (p<0.05). Incidence of liver tumor development was also lower in red ginseng extracts-treated group, although the difference from control group was not statistically significant. Anti-carcinogenic activity of white ginseng extracts, besides red ginseng extracts, was also investigated. In the present study, the administration of white ginseng extracts was proven to suppress tumor promoter-induced phenomena in vitro and in vivo. It is of interest that oral administration of the extracts of Ren-Shen-Yang- Rong-Tang, a white ginseng-containing Chinese medicinal prescription, resulted in the suppression of skin tumor promotion by 12-o-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated CD-1 mice. These results suggest the usefulness of ginseng in the field of cancer prevention.
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U2 - 10.3346/jkms.2001.16.S.S66
DO - 10.3346/jkms.2001.16.S.S66
M3 - Article
C2 - 11748379
AN - SCOPUS:0035650874
SN - 1011-8934
VL - 16 Suppl
SP - S66-69
JO - Journal of Korean medical science
JF - Journal of Korean medical science
ER -