Cancer chemoprevention by ginseng in mouse liver and other organs.

H. Nishino, H. Tokuda, T. Ii, M. Takemura, M. Kuchide, M. Kanazawa, X. Y. Mou, P. Bu, J. Takayasu, M. Onozuka, M. Masuda, Y. Satomi, T. Konoshima, N. Kishi, M. Baba, Y. Okada, T. Okuyama

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Abstract

Oral administration of red ginseng extracts (1% in diet for 40 weeks) resulted in the significant suppression of spontaneous liver tumor formation in C3H/He male mice. Average number of tumors per mouse in control group was 1.06, while that in red ginseng extracts-treated group was 0.33 (p<0.05). Incidence of liver tumor development was also lower in red ginseng extracts-treated group, although the difference from control group was not statistically significant. Anti-carcinogenic activity of white ginseng extracts, besides red ginseng extracts, was also investigated. In the present study, the administration of white ginseng extracts was proven to suppress tumor promoter-induced phenomena in vitro and in vivo. It is of interest that oral administration of the extracts of Ren-Shen-Yang- Rong-Tang, a white ginseng-containing Chinese medicinal prescription, resulted in the suppression of skin tumor promotion by 12-o-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated CD-1 mice. These results suggest the usefulness of ginseng in the field of cancer prevention.

Original languageEnglish (US)
Pages (from-to)S66-69
JournalJournal of Korean medical science
Volume16 Suppl
DOIs
StatePublished - Dec 2001

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Nishino, H., Tokuda, H., Ii, T., Takemura, M., Kuchide, M., Kanazawa, M., Mou, X. Y., Bu, P., Takayasu, J., Onozuka, M., Masuda, M., Satomi, Y., Konoshima, T., Kishi, N., Baba, M., Okada, Y., & Okuyama, T. (2001). Cancer chemoprevention by ginseng in mouse liver and other organs. Journal of Korean medical science, 16 Suppl, S66-69. https://doi.org/10.3346/jkms.2001.16.S.S66