Blockade of D-1 receptors by SCH 23390 antagonizes morphine- and amphetamine-induced place preference conditioning

Paola Leone; Gaetano Di Chiara

doi:10.1016/0014-2999(87)90621-2

Blockade of D-1 receptors by SCH 23390 antagonizes morphine- and amphetamine-induced place preference conditioning

Paola Leone, Gaetano Di Chiara

Research output: Contribution to journal › Article › peer-review

154 Scopus citations

Abstract

Morphine (0.5 mg/kg s.c). and amphetamine (1 mg/kg s.c.) used in a two-compartment place preference test induced strong place preference when paired to the non-preferred environments. They did not modify preference under basal conditions but completely reversed morphine- and amphetamine-induced place preference. Pairing of haloperidol (0.2 mg/kg s.c) to both environments also abolished the morphine-induced place preference.

Original language	English (US)
Pages (from-to)	251-254
Number of pages	4
Journal	European Journal of Pharmacology
Volume	135
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(87)90621-2
State	Published - Mar 17 1987
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1016/0014-2999(87)90621-2

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title = "Blockade of D-1 receptors by SCH 23390 antagonizes morphine- and amphetamine-induced place preference conditioning",

abstract = "Morphine (0.5 mg/kg s.c). and amphetamine (1 mg/kg s.c.) used in a two-compartment place preference test induced strong place preference when paired to the non-preferred environments. They did not modify preference under basal conditions but completely reversed morphine- and amphetamine-induced place preference. Pairing of haloperidol (0.2 mg/kg s.c) to both environments also abolished the morphine-induced place preference.",

author = "Paola Leone and {Di Chiara}, Gaetano",

note = "Funding Information: This work was performed with the support of grants from C.N.R., progetto finalizzato 'Tossicodipendenze'. We thank Prof. Vera Maxia for advice on the statistics.",

year = "1987",

month = mar,

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doi = "10.1016/0014-2999(87)90621-2",

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AU - Leone, Paola

AU - Di Chiara, Gaetano

N1 - Funding Information: This work was performed with the support of grants from C.N.R., progetto finalizzato 'Tossicodipendenze'. We thank Prof. Vera Maxia for advice on the statistics.

PY - 1987/3/17

Y1 - 1987/3/17

N2 - Morphine (0.5 mg/kg s.c). and amphetamine (1 mg/kg s.c.) used in a two-compartment place preference test induced strong place preference when paired to the non-preferred environments. They did not modify preference under basal conditions but completely reversed morphine- and amphetamine-induced place preference. Pairing of haloperidol (0.2 mg/kg s.c) to both environments also abolished the morphine-induced place preference.

AB - Morphine (0.5 mg/kg s.c). and amphetamine (1 mg/kg s.c.) used in a two-compartment place preference test induced strong place preference when paired to the non-preferred environments. They did not modify preference under basal conditions but completely reversed morphine- and amphetamine-induced place preference. Pairing of haloperidol (0.2 mg/kg s.c) to both environments also abolished the morphine-induced place preference.

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Blockade of D-1 receptors by SCH 23390 antagonizes morphine- and amphetamine-induced place preference conditioning

Abstract

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