Bistratamides E-J, modified cyclic hexapeptides from the Philippines ascidian Lissoclinum bistratum

Lark J. Perez; D. John Faulkner; Wiliam Fenical

doi:10.1021/np0204601

Bistratamides E-J, modified cyclic hexapeptides from the Philippines ascidian Lissoclinum bistratum

Lark J. Perez, D. John Faulkner, Wiliam Fenical

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

The Philippines ascidian Lissoclinum bistratum contained the known metabolites bistratamides C and D, together with six novel modified cyclic hexapeptides, bistratamides E-J. The structures of bistratamides E-J were elucidated by interpretation of spectral data, and the absolute stereochemistry of the constituent amino acids was determined after ozonolysis and acid-catalyzed hydrolysis. Bistratamides E-J were moderately cytotoxic in the HCT-116 cell line assay.

Original language	English (US)
Pages (from-to)	247-250
Number of pages	4
Journal	Journal of Natural Products
Volume	66
Issue number	2
DOIs	https://doi.org/10.1021/np0204601
State	Published - Feb 1 2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np0204601

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abstract = "The Philippines ascidian Lissoclinum bistratum contained the known metabolites bistratamides C and D, together with six novel modified cyclic hexapeptides, bistratamides E-J. The structures of bistratamides E-J were elucidated by interpretation of spectral data, and the absolute stereochemistry of the constituent amino acids was determined after ozonolysis and acid-catalyzed hydrolysis. Bistratamides E-J were moderately cytotoxic in the HCT-116 cell line assay.",

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