Bistratamides E-J, modified cyclic hexapeptides from the Philippines ascidian Lissoclinum bistratum

Lark J. Perez, D. John Faulkner, Wiliam Fenical

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

The Philippines ascidian Lissoclinum bistratum contained the known metabolites bistratamides C and D, together with six novel modified cyclic hexapeptides, bistratamides E-J. The structures of bistratamides E-J were elucidated by interpretation of spectral data, and the absolute stereochemistry of the constituent amino acids was determined after ozonolysis and acid-catalyzed hydrolysis. Bistratamides E-J were moderately cytotoxic in the HCT-116 cell line assay.

Original languageEnglish (US)
Pages (from-to)247-250
Number of pages4
JournalJournal of Natural Products
Volume66
Issue number2
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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