Abstract
The Philippines ascidian Lissoclinum bistratum contained the known metabolites bistratamides C and D, together with six novel modified cyclic hexapeptides, bistratamides E-J. The structures of bistratamides E-J were elucidated by interpretation of spectral data, and the absolute stereochemistry of the constituent amino acids was determined after ozonolysis and acid-catalyzed hydrolysis. Bistratamides E-J were moderately cytotoxic in the HCT-116 cell line assay.
Original language | English (US) |
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Pages (from-to) | 247-250 |
Number of pages | 4 |
Journal | Journal of Natural Products |
Volume | 66 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2003 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry