Bioprinters for organs-on-chips

Amir K. Miri, Ebrahim Mostafavi, Danial Khorsandi, Shu Kai Hu, Matthew Malpica, Ali Khademhosseini

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

Recent advances in bioprinting technologies have enabled rapid manufacturing of organ-on-chip models along with biomimetic tissue microarchitectures. Bioprinting techniques can be used to integrate microfluidic channels and flow connections in organ-on-chip models. We review bioprinters in two categories of nozzle-based and optical-based methods, and then discuss their fabrication parameters such as resolution, replication fidelity, fabrication time, and cost for micro-tissue models and microfluidic applications. The use of bioprinters has shown successful replicates of functional engineered tissue models integrated within a desired microfluidic system, which facilitates the observation of metabolism or secretion of models and sophisticated control of a dynamic environment. This may provide a wider order of tissue engineering fabrication in mimicking physiological conditions for enhancing further applications such as drug development and pathological studies.

Original languageEnglish (US)
Article number042002
JournalBiofabrication
Volume11
Issue number4
DOIs
StatePublished - Sep 20 2019

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Biomaterials
  • Biomedical Engineering

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