Biomimetic hydrogels for enhanced loading and extended release of ocular therapeutics

Siddarth Venkatesh, Stephen P. Sizemore, Mark E. Byrne

    Research output: Contribution to journalArticlepeer-review

    120 Scopus citations

    Abstract

    We have applied the principles of biomimesis by incorporating a natural receptor-based rational design strategy in the synthesis of novel recognitive soft contact lenses. We have demonstrated the potential of biomimetic carriers to load significant amounts of ocular medication such as H1-antihistamines, as well as to release a therapeutic dosage of drug in vitro in a controlled fashion for 5 days, with an even further extension in the presence of protein. Gels of multiple complexation points with varying functionalities outperformed gels formed with less diverse functional monomers and showed superior loading with a six-fold difference over control gels and a three-fold difference over less biomimetic gels. Moreover, mechanical and optical properties of these hydrogels agreed with conventional lenses, and increased loading was reflected in a reduced propagation of polymer chains. This approach can be extended to a wider biological spectrum in the design of novel, controlled and modulated delivery devices to alleviate ocular disorders and provide an alternative to topical therapy.

    Original languageEnglish (US)
    Pages (from-to)717-724
    Number of pages8
    JournalBiomaterials
    Volume28
    Issue number4
    DOIs
    StatePublished - Feb 1 2007

    All Science Journal Classification (ASJC) codes

    • Bioengineering
    • Ceramics and Composites
    • Biophysics
    • Biomaterials
    • Mechanics of Materials

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