TY - JOUR
T1 - Benzoboroxoles
T2 - Synthesis and applications in medicinal chemistry
AU - Mereddy, Gautam R.
AU - Chakradhar, Anjali
AU - Rutkoski, Ryan M.
AU - Jonnalagadda, Subash C.
N1 - Funding Information:
We thank the Departments of Chemistry and Biochemistry and of Molecular and Cellular Biosciences, Rowan University. Partial support of this work was provided by grants from Rowan University Seed Funding, Avante Pharma and Channel Therapeutics.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/6/15
Y1 - 2018/6/15
N2 - Benzoboroxoles are cyclic boronic acids and they have gained significant attention amongst the organic and medicinal chemistry community in recent years with the approval of benzoboroxole based drugs such as tavaborole for onychomycosis and crisaborole for atopic dermatitis. There have been numerous other benzoboroxole-based compounds identified that exhibit excellent biological activity against wide variety of diseases. Much of the recent literature describes the preparation of functionalized benzoboroxoles and their applications in organic synthesis, materials, and medicinal chemistry. This review outlines the various methods reported for the synthesis of this class of compounds along with few recent applications of benzoboroxoles in medicinal chemistry.
AB - Benzoboroxoles are cyclic boronic acids and they have gained significant attention amongst the organic and medicinal chemistry community in recent years with the approval of benzoboroxole based drugs such as tavaborole for onychomycosis and crisaborole for atopic dermatitis. There have been numerous other benzoboroxole-based compounds identified that exhibit excellent biological activity against wide variety of diseases. Much of the recent literature describes the preparation of functionalized benzoboroxoles and their applications in organic synthesis, materials, and medicinal chemistry. This review outlines the various methods reported for the synthesis of this class of compounds along with few recent applications of benzoboroxoles in medicinal chemistry.
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U2 - 10.1016/j.jorganchem.2018.03.017
DO - 10.1016/j.jorganchem.2018.03.017
M3 - Article
AN - SCOPUS:85044254541
SN - 0022-328X
VL - 865
SP - 12
EP - 22
JO - Journal of Organometallic Chemistry
JF - Journal of Organometallic Chemistry
ER -