Basic and clinical studies with corticotropin-releasing hormone. Implications for a possible role in panic disorder

P. W. Gold; T. A. Pigott; M. A. Kling; K. Kalogeras; G. P. Chrousos

doi:10.1016/s0193-953x(18)30500-8

Basic and clinical studies with corticotropin-releasing hormone. Implications for a possible role in panic disorder

P. W. Gold, T. A. Pigott, M. A. Kling, K. Kalogeras, G. P. Chrousos

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

We have presented several lines of circumstantial evidence suggesting a possible role for CRH in the panic disorder syndrome. Such a role has by no means demonstrated and is indeed challenged by several lines of contradictory data. Clinical evaluation of this hypothesis must await further basic research on the role of hypothalamic and extrahypothalamic CRH in stress-mediated phenomena and on their interrelationships. Moreover, additional clinical research will be required to further delineate the landscape of hypothalamic-pituitary-adrenal function in patients with panic disorder both during acute panic episodes and intercurrently.

Original language	English (US)
Pages (from-to)	327-334
Number of pages	8
Journal	Psychiatric Clinics of North America
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/s0193-953x(18)30500-8
State	Published - 1988
Externally published	Yes

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health

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10.1016/s0193-953x(18)30500-8

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title = "Basic and clinical studies with corticotropin-releasing hormone. Implications for a possible role in panic disorder",

abstract = "We have presented several lines of circumstantial evidence suggesting a possible role for CRH in the panic disorder syndrome. Such a role has by no means demonstrated and is indeed challenged by several lines of contradictory data. Clinical evaluation of this hypothesis must await further basic research on the role of hypothalamic and extrahypothalamic CRH in stress-mediated phenomena and on their interrelationships. Moreover, additional clinical research will be required to further delineate the landscape of hypothalamic-pituitary-adrenal function in patients with panic disorder both during acute panic episodes and intercurrently.",

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AU - Pigott, T. A.

AU - Kling, M. A.

AU - Kalogeras, K.

AU - Chrousos, G. P.

PY - 1988

Y1 - 1988

N2 - We have presented several lines of circumstantial evidence suggesting a possible role for CRH in the panic disorder syndrome. Such a role has by no means demonstrated and is indeed challenged by several lines of contradictory data. Clinical evaluation of this hypothesis must await further basic research on the role of hypothalamic and extrahypothalamic CRH in stress-mediated phenomena and on their interrelationships. Moreover, additional clinical research will be required to further delineate the landscape of hypothalamic-pituitary-adrenal function in patients with panic disorder both during acute panic episodes and intercurrently.

AB - We have presented several lines of circumstantial evidence suggesting a possible role for CRH in the panic disorder syndrome. Such a role has by no means demonstrated and is indeed challenged by several lines of contradictory data. Clinical evaluation of this hypothesis must await further basic research on the role of hypothalamic and extrahypothalamic CRH in stress-mediated phenomena and on their interrelationships. Moreover, additional clinical research will be required to further delineate the landscape of hypothalamic-pituitary-adrenal function in patients with panic disorder both during acute panic episodes and intercurrently.

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Basic and clinical studies with corticotropin-releasing hormone. Implications for a possible role in panic disorder

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