Binding of cross-reactive autoantibodies to peptidylarginine deiminase 4 (PAD4) increases its activity by lowering its requirement for Ca2+, leading to increased production of citrullinated autoantigens and worse outcomes in patients with rheumatoid arthritis (Darrah et al., this issue).
|Original language||English (US)|
|Journal||Science Translational Medicine|
|State||Published - May 22 2013|
All Science Journal Classification (ASJC) codes
FingerprintDive into the research topics of 'Autoantibodies: Double agents in human disease'. Together they form a unique fingerprint.
New Jersey Institute for Successful Aging (NJISA)
Anita Chopra (Manager), Elyse Perweiler (Other), Rachel Pruchno (Other) & Robert Nagele (Other)Geriatric - NJISA