Autoantibodies: Double agents in human disease

Nimish K. Acharya; Eric P. Nagele; Min Han; Robert Nagele

doi:10.1126/scitranslmed.3006288

Autoantibodies: Double agents in human disease

Nimish K. Acharya, Eric P. Nagele, Min Han, Robert Nagele

Research output: Contribution to journal › Comment/debate › peer-review

9 Scopus citations

Abstract

Binding of cross-reactive autoantibodies to peptidylarginine deiminase 4 (PAD4) increases its activity by lowering its requirement for Ca²⁺, leading to increased production of citrullinated autoantigens and worse outcomes in patients with rheumatoid arthritis (Darrah et al., this issue).

Original language	English (US)
Article number	186fs19
Journal	Science Translational Medicine
Volume	5
Issue number	186
DOIs	https://doi.org/10.1126/scitranslmed.3006288
State	Published - May 22 2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1126/scitranslmed.3006288

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@article{044544b2a3134061920fafda117ecea5,

title = "Autoantibodies: Double agents in human disease",

abstract = "Binding of cross-reactive autoantibodies to peptidylarginine deiminase 4 (PAD4) increases its activity by lowering its requirement for Ca2+, leading to increased production of citrullinated autoantigens and worse outcomes in patients with rheumatoid arthritis (Darrah et al., this issue).",

author = "Acharya, {Nimish K.} and Nagele, {Eric P.} and Min Han and Robert Nagele",

year = "2013",

month = may,

day = "22",

doi = "10.1126/scitranslmed.3006288",

language = "English (US)",

volume = "5",

journal = "Science Translational Medicine",

issn = "1946-6234",

publisher = "American Association for the Advancement of Science",

number = "186",

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T1 - Autoantibodies

T2 - Double agents in human disease

AU - Acharya, Nimish K.

AU - Nagele, Eric P.

AU - Han, Min

AU - Nagele, Robert

PY - 2013/5/22

Y1 - 2013/5/22

N2 - Binding of cross-reactive autoantibodies to peptidylarginine deiminase 4 (PAD4) increases its activity by lowering its requirement for Ca2+, leading to increased production of citrullinated autoantigens and worse outcomes in patients with rheumatoid arthritis (Darrah et al., this issue).

AB - Binding of cross-reactive autoantibodies to peptidylarginine deiminase 4 (PAD4) increases its activity by lowering its requirement for Ca2+, leading to increased production of citrullinated autoantigens and worse outcomes in patients with rheumatoid arthritis (Darrah et al., this issue).

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U2 - 10.1126/scitranslmed.3006288

DO - 10.1126/scitranslmed.3006288

M3 - Comment/debate

C2 - 23698377

AN - SCOPUS:84878310738

SN - 1946-6234

VL - 5

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 186

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ER -

Autoantibodies: Double agents in human disease

Abstract

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New Jersey Institute for Successful Aging (NJISA)

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Autoantibodies: Double agents in human disease

Abstract

All Science Journal Classification (ASJC) codes

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New Jersey Institute for Successful Aging (NJISA)

Cite this