Autoantibodies: Double agents in human disease

Nimish K. Acharya, Eric P. Nagele, Min Han, Robert Nagele

Research output: Contribution to journalComment/debate

6 Scopus citations

Abstract

Binding of cross-reactive autoantibodies to peptidylarginine deiminase 4 (PAD4) increases its activity by lowering its requirement for Ca2+, leading to increased production of citrullinated autoantigens and worse outcomes in patients with rheumatoid arthritis (Darrah et al., this issue).

Original languageEnglish (US)
Article number186fs19
JournalScience Translational Medicine
Volume5
Issue number186
DOIs
StatePublished - May 22 2013
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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