Autoantibodies: Double agents in human disease

Nimish K. Acharya, Eric P. Nagele, Min Han, Robert Nagele

Research output: Contribution to journalComment/debatepeer-review

9 Scopus citations


Binding of cross-reactive autoantibodies to peptidylarginine deiminase 4 (PAD4) increases its activity by lowering its requirement for Ca2+, leading to increased production of citrullinated autoantigens and worse outcomes in patients with rheumatoid arthritis (Darrah et al., this issue).

Original languageEnglish (US)
Article number186fs19
JournalScience Translational Medicine
Issue number186
StatePublished - May 22 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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