Abstract
The goal of this preliminary proof-of-concept study was to use human protein microarrays to identify blood-based autoantibody biomarkers capable of diagnosing multiple sclerosis (MS). Using sera from 112 subjects, including 51 MS subjects, autoantibody biomarkers effectively differentiated MS subjects from age- and gender-matched normal and breast cancer controls with 95.0% and 100% overall accuracy, but not from subjects with Parkinson's disease. Autoantibody biomarkers were also useful in distinguishing subjects with the relapsing-remitting form of MS from those with the secondary progressive subtype. These results demonstrate that autoantibodies can be used as noninvasive blood-based biomarkers for the detection and subtyping of MS.
Original language | English (US) |
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Pages (from-to) | 51-57 |
Number of pages | 7 |
Journal | Journal of Neuroimmunology |
Volume | 309 |
DOIs | |
State | Published - Aug 15 2017 |
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology
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New Jersey Institute for Successful Aging (NJISA)
Anita Chopra (Manager), Elyse Perweiler (Other), Rachel Pruchno (Other) & Robert Nagele (Other)
Geriatric - NJISAEquipment/facility: Facility