TY - JOUR
T1 - Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression
AU - De Bellis, Michael D.
AU - Gold, Philip W.
AU - Geracioti, Thomas D.
AU - Listwak, Samuel J.
AU - Kling, Mitchel A.
PY - 1993
Y1 - 1993
N2 - The authors measured CSF concentrations of corticotropin-releasing hormone (CRH) and arginine vasopressin in nine depressed patients before and after fluoxetine treatment. They found significant decreases in CSF CRH, CSF arginine vasopressin, and Hamilton depression ratings. Thus, the therapeutic effect of this serotonin-uptake inhibitor may be related to diminution of these arousal-promoting neuropeptides.
AB - The authors measured CSF concentrations of corticotropin-releasing hormone (CRH) and arginine vasopressin in nine depressed patients before and after fluoxetine treatment. They found significant decreases in CSF CRH, CSF arginine vasopressin, and Hamilton depression ratings. Thus, the therapeutic effect of this serotonin-uptake inhibitor may be related to diminution of these arousal-promoting neuropeptides.
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U2 - 10.1176/ajp.150.4.656
DO - 10.1176/ajp.150.4.656
M3 - Article
C2 - 8465888
AN - SCOPUS:0027503187
SN - 0002-953X
VL - 150
SP - 656
EP - 657
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 4
ER -