Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence

Falk W. Lohoff, Paul J. Bloch, Thomas N. Ferraro, Wade H. Berrettini, Helen M. Pettinati, Charles A. Dackis, Charles P. O'Brien, Kyle M. Kampman, David W. Oslin

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4 Scopus citations

Abstract

Cocaine-induced neuroplasticity changes in the mesocorticolimbic dopamine systems are thought to be involved in the pathophysiology of cocaine dependence. Since neurotrophic factors have been observed to prevent/reverse and mimic cocaine-induced neurobiological changes in the brain, related genes are plausible candidates for susceptibility to cocaine dependence. The novel conserved dopamine neurotrophic factor protein (CDNF) promotes the survival, growth, and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity. In this study, we hypothesize that polymorphisms in the CDNF gene (CDNF/ARMETL1) contribute to increased risk for cocaine dependence. Cocaine dependent individuals (n = 351) and unaffected controls (n = 257) of African descent were genotyped for four single nucleotide polymorphisms (SNPs) in the CDNF gene (rs11259365, rs7094179, rs7900873, rs2278871). We observed no significant differences in allele, genotype, or haplotype frequencies between cases and controls for any of the tested SNPs. Our study suggests that there is no association between variants in the CDNF gene and cocaine dependence. However, additional studies using larger sample sizes, comprehensive SNP coverage, and clinically homogenous populations are necessary before confidently excluding CDNF as a significant genetic risk factor for cocaine dependence.

Original languageEnglish (US)
Pages (from-to)199-203
Number of pages5
JournalNeuroscience Letters
Volume453
Issue number3
DOIs
StatePublished - Apr 10 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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    Lohoff, F. W., Bloch, P. J., Ferraro, T. N., Berrettini, W. H., Pettinati, H. M., Dackis, C. A., O'Brien, C. P., Kampman, K. M., & Oslin, D. W. (2009). Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence. Neuroscience Letters, 453(3), 199-203. https://doi.org/10.1016/j.neulet.2009.02.026