Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis

Junko Ishida; Mutsuo Kozuka; Hui Kang Wang; Takao Konoshima; Harukuni Tokuda; Masato Okuda; Xiao Yang Mou; Hoyoku Nishino; Nobuko Sakurai; Kuo Hsiung Lee; Masahiro Nagai

doi:10.1016/S0304-3835(00)00538-3

Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis

Junko Ishida, Mutsuo Kozuka, Hui Kang Wang, Takao Konoshima, Harukuni Tokuda, Masato Okuda, Xiao Yang Mou, Hoyoku Nishino, Nobuko Sakurai, Kuo Hsiung Lee, Masahiro Nagai

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Abstract

Eleven cyclic diarylheptanoids were screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. 13-Oxomyricanol and myricanone showed the highest activity and also exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These data suggest that certain diarylheptanoids might be valuable antitumor promoters and/or chemopreventors. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	135-140
Number of pages	6
Journal	Cancer Letters
Volume	159
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(00)00538-3
State	Published - Oct 31 2000
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1016/S0304-3835(00)00538-3

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@article{69e6da6e7d2347cba4b662771e3261bc,

title = "Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis",

abstract = "Eleven cyclic diarylheptanoids were screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. 13-Oxomyricanol and myricanone showed the highest activity and also exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These data suggest that certain diarylheptanoids might be valuable antitumor promoters and/or chemopreventors. (C) 2000 Elsevier Science Ireland Ltd.",

author = "Junko Ishida and Mutsuo Kozuka and Wang, {Hui Kang} and Takao Konoshima and Harukuni Tokuda and Masato Okuda and {Yang Mou}, Xiao and Hoyoku Nishino and Nobuko Sakurai and Lee, {Kuo Hsiung} and Masahiro Nagai",

note = "Funding Information: This investigation was supported in part by a grant from the National Cancer Institute (CA17625) awarded to K.H. Lee and from the Ministry of Education, Science, Sports and Culture, and Ministry of Health and Welfare, Japan.",

year = "2000",

month = oct,

day = "31",

doi = "10.1016/S0304-3835(00)00538-3",

language = "English (US)",

volume = "159",

pages = "135--140",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

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TY - JOUR

T1 - Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis

AU - Ishida, Junko

AU - Kozuka, Mutsuo

AU - Wang, Hui Kang

AU - Konoshima, Takao

AU - Tokuda, Harukuni

AU - Okuda, Masato

AU - Yang Mou, Xiao

AU - Nishino, Hoyoku

AU - Sakurai, Nobuko

AU - Lee, Kuo Hsiung

AU - Nagai, Masahiro

N1 - Funding Information: This investigation was supported in part by a grant from the National Cancer Institute (CA17625) awarded to K.H. Lee and from the Ministry of Education, Science, Sports and Culture, and Ministry of Health and Welfare, Japan.

PY - 2000/10/31

Y1 - 2000/10/31

N2 - Eleven cyclic diarylheptanoids were screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. 13-Oxomyricanol and myricanone showed the highest activity and also exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These data suggest that certain diarylheptanoids might be valuable antitumor promoters and/or chemopreventors. (C) 2000 Elsevier Science Ireland Ltd.

AB - Eleven cyclic diarylheptanoids were screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. 13-Oxomyricanol and myricanone showed the highest activity and also exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These data suggest that certain diarylheptanoids might be valuable antitumor promoters and/or chemopreventors. (C) 2000 Elsevier Science Ireland Ltd.

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DO - 10.1016/S0304-3835(00)00538-3

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SN - 0304-3835

VL - 159

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JO - Cancer Letters

JF - Cancer Letters

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ER -

Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis

Abstract

All Science Journal Classification (ASJC) codes

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