Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis

Junko Ishida, Mutsuo Kozuka, Hui Kang Wang, Takao Konoshima, Harukuni Tokuda, Masato Okuda, Xiao Yang Mou, Hoyoku Nishino, Nobuko Sakurai, Kuo Hsiung Lee, Masahiro Nagai

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Eleven cyclic diarylheptanoids were screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. 13-Oxomyricanol and myricanone showed the highest activity and also exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These data suggest that certain diarylheptanoids might be valuable antitumor promoters and/or chemopreventors. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)135-140
Number of pages6
JournalCancer Letters
Volume159
Issue number2
DOIs
StatePublished - Oct 31 2000

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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