Antitumor promoting activities of 3-O-acyl-(-)-epigallocatechins

Shinichi Uesato, Yutaka Kitagawa, Yukihiko Hara, Harukuni Tokuda, Masato Okuda, Xiao Yang Mou, Teruo Mukainaka, Hoyoku Nishino

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

As an exploratory investigation of antitumor promoting compounds, 3-O-acyl-(-)-epigallocatechins possessing a straight-, branched-, phenyl-inserted- or 1,4-phenylene-inserted-acyl chain of varying length from C4 to C18 were synthesized and evaluated their inhibitory effects against the activation of the Epstein-Barr virus early antigen (EBV-EA). It was indicated that the epigallocatechin derivatives having the straight- or branched-acyl chain of C8 to C11 carbon atoms achieve marked effects. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish (US)
Pages (from-to)1673-1675
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number15
DOIs
StatePublished - Aug 7 2000

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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