Antitumor promoting activities of 3-O-acyl-(-)-epigallocatechins

Shinichi Uesato; Yutaka Kitagawa; Yukihiko Hara; Harukuni Tokuda; Masato Okuda; Xiao Yang Mou; Teruo Mukainaka; Hoyoku Nishino

doi:10.1016/S0960-894X(00)00314-0

Antitumor promoting activities of 3-O-acyl-(-)-epigallocatechins

Shinichi Uesato, Yutaka Kitagawa, Yukihiko Hara, Harukuni Tokuda, Masato Okuda, Xiao Yang Mou, Teruo Mukainaka, Hoyoku Nishino

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

As an exploratory investigation of antitumor promoting compounds, 3-O-acyl-(-)-epigallocatechins possessing a straight-, branched-, phenyl-inserted- or 1,4-phenylene-inserted-acyl chain of varying length from C₄ to C₁₈ were synthesized and evaluated their inhibitory effects against the activation of the Epstein-Barr virus early antigen (EBV-EA). It was indicated that the epigallocatechin derivatives having the straight- or branched-acyl chain of C₈ to C₁₁ carbon atoms achieve marked effects. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English (US)
Pages (from-to)	1673-1675
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	15
DOIs	https://doi.org/10.1016/S0960-894X(00)00314-0
State	Published - Aug 7 2000
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)00314-0

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title = "Antitumor promoting activities of 3-O-acyl-(-)-epigallocatechins",

abstract = "As an exploratory investigation of antitumor promoting compounds, 3-O-acyl-(-)-epigallocatechins possessing a straight-, branched-, phenyl-inserted- or 1,4-phenylene-inserted-acyl chain of varying length from C4 to C18 were synthesized and evaluated their inhibitory effects against the activation of the Epstein-Barr virus early antigen (EBV-EA). It was indicated that the epigallocatechin derivatives having the straight- or branched-acyl chain of C8 to C11 carbon atoms achieve marked effects. (C) 2000 Elsevier Science Ltd. All rights reserved.",

author = "Shinichi Uesato and Yutaka Kitagawa and Yukihiko Hara and Harukuni Tokuda and Masato Okuda and Mou, {Xiao Yang} and Teruo Mukainaka and Hoyoku Nishino",

note = "Funding Information: This work has been partially financed by OSEO under the QUAERO program. Part of the research has been supported by a Luxembourgish FNR grant awarded to N.D.S.",

year = "2000",

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doi = "10.1016/S0960-894X(00)00314-0",

language = "English (US)",

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TY - JOUR

T1 - Antitumor promoting activities of 3-O-acyl-(-)-epigallocatechins

AU - Uesato, Shinichi

AU - Kitagawa, Yutaka

AU - Hara, Yukihiko

AU - Tokuda, Harukuni

AU - Okuda, Masato

AU - Mou, Xiao Yang

AU - Mukainaka, Teruo

AU - Nishino, Hoyoku

N1 - Funding Information: This work has been partially financed by OSEO under the QUAERO program. Part of the research has been supported by a Luxembourgish FNR grant awarded to N.D.S.

PY - 2000/8/7

Y1 - 2000/8/7

N2 - As an exploratory investigation of antitumor promoting compounds, 3-O-acyl-(-)-epigallocatechins possessing a straight-, branched-, phenyl-inserted- or 1,4-phenylene-inserted-acyl chain of varying length from C4 to C18 were synthesized and evaluated their inhibitory effects against the activation of the Epstein-Barr virus early antigen (EBV-EA). It was indicated that the epigallocatechin derivatives having the straight- or branched-acyl chain of C8 to C11 carbon atoms achieve marked effects. (C) 2000 Elsevier Science Ltd. All rights reserved.

AB - As an exploratory investigation of antitumor promoting compounds, 3-O-acyl-(-)-epigallocatechins possessing a straight-, branched-, phenyl-inserted- or 1,4-phenylene-inserted-acyl chain of varying length from C4 to C18 were synthesized and evaluated their inhibitory effects against the activation of the Epstein-Barr virus early antigen (EBV-EA). It was indicated that the epigallocatechin derivatives having the straight- or branched-acyl chain of C8 to C11 carbon atoms achieve marked effects. (C) 2000 Elsevier Science Ltd. All rights reserved.

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 15

ER -

Antitumor promoting activities of 3-O-acyl-(-)-epigallocatechins

Abstract

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