Abstract
In the present study we report that 4,5-dihydroxy-2-cyclopentan-1-one (DHCP), which is derived from heat-treatment of uronic acid or its derivatives, has antibacterial activity against Escherichia coli. The compound causes complete growth inhibition at 350 μM concentration. We have cloned a gene from E. coli, which confers DHCP resistance when present in multicopy. The putative protein encoded by this gene (dep - DHCP efflux protein) is a transmembrane efflux protein with a high homology to other antibiotic-efflux proteins including those for chloramphenicol, bicyclomycin and tetracycline. However, the Dep protein does not confer cross-resistance to any of the antibiotics tested.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 461-465 |
| Number of pages | 5 |
| Journal | Journal of Molecular Microbiology and Biotechnology |
| Volume | 3 |
| Issue number | 3 |
| State | Published - 2001 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biotechnology
- Microbiology
- Applied Microbiology and Biotechnology
- Molecular Biology