Analysis of the in vitro swelling behavior of poly(vinyl alcohol) hydrogels in osmotic pressure solution for soft tissue replacement

Julianne L. Holloway; Kara L. Spiller; Anthony M. Lowman; Giuseppe R. Palmese

doi:10.1016/j.actbio.2011.02.016

Analysis of the in vitro swelling behavior of poly(vinyl alcohol) hydrogels in osmotic pressure solution for soft tissue replacement

Julianne L. Holloway, Kara L. Spiller, Anthony M. Lowman, Giuseppe R. Palmese

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

An osmotic solution was used to evaluate poly(vinyl alcohol) (PVA) hydrogels as potential non-degradable soft tissue replacements in vitro. Osmotic solutions are necessary in order to mimic the swelling pressure observed in vivo for soft tissues present in load-bearing joints. In vitro studies indicated that PVA hydrogels experience minimal changes in swelling with a polymer concentration of 20 wt.% PVA in phosphate-buffered saline solution (0 atm) and between 30 and 35 wt.% PVA in osmotic solution with a pressure of 0.95 atm. Swelling in osmotic pressure solutions caused decreases in the equilibrium hydrogel hydration. An investigation of hydrogel compressive modulus indicated that PVA hydrogels are within the range of articular cartilage, meniscal tissue, and the temporomandibular joint disk. Furthermore, it is possible to tailor PVA hydrogels through careful modification of the polymer concentration and freeze-thaw cycles during hydrogel preparation to match both a desired swelling ratio and a desired compressive modulus or porosity. The microstructure of the PVA hydrogels was also evaluated as a function of freeze-thaw cycles and polymer concentration to give an insight into the processes occurring during synthesis and swelling in osmotic solutions.

Original language	English (US)
Pages (from-to)	2477-2482
Number of pages	6
Journal	Acta Biomaterialia
Volume	7
Issue number	6
DOIs	https://doi.org/10.1016/j.actbio.2011.02.016
State	Published - Jun 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biotechnology
Biomaterials
Biochemistry
Biomedical Engineering
Molecular Biology

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10.1016/j.actbio.2011.02.016

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title = "Analysis of the in vitro swelling behavior of poly(vinyl alcohol) hydrogels in osmotic pressure solution for soft tissue replacement",

abstract = "An osmotic solution was used to evaluate poly(vinyl alcohol) (PVA) hydrogels as potential non-degradable soft tissue replacements in vitro. Osmotic solutions are necessary in order to mimic the swelling pressure observed in vivo for soft tissues present in load-bearing joints. In vitro studies indicated that PVA hydrogels experience minimal changes in swelling with a polymer concentration of 20 wt.% PVA in phosphate-buffered saline solution (0 atm) and between 30 and 35 wt.% PVA in osmotic solution with a pressure of 0.95 atm. Swelling in osmotic pressure solutions caused decreases in the equilibrium hydrogel hydration. An investigation of hydrogel compressive modulus indicated that PVA hydrogels are within the range of articular cartilage, meniscal tissue, and the temporomandibular joint disk. Furthermore, it is possible to tailor PVA hydrogels through careful modification of the polymer concentration and freeze-thaw cycles during hydrogel preparation to match both a desired swelling ratio and a desired compressive modulus or porosity. The microstructure of the PVA hydrogels was also evaluated as a function of freeze-thaw cycles and polymer concentration to give an insight into the processes occurring during synthesis and swelling in osmotic solutions.",

author = "Holloway, {Julianne L.} and Spiller, {Kara L.} and Lowman, {Anthony M.} and Palmese, {Giuseppe R.}",

note = "Funding Information: The authors from Drexel University wish to acknowledge Lauren Santi and Drexel University College of Medicine for use of the cryostat and optical microscope. Additionally, Mark Vanlandingham from the Army Research Labs in Aberdeen, MD, and Suzanne Maher from the Hospital for Special Surgery in New York, NY, provided valuable insight over the course of this research. Funding for this project was provided by the Department of Defense through the National Defense Science and Engineering Graduate Fellowship, in addition to the US Army Research Laboratory through the Army Materials Center of Excellence Program, contract W911NF-06-2-0013. ",

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AU - Palmese, Giuseppe R.

N1 - Funding Information: The authors from Drexel University wish to acknowledge Lauren Santi and Drexel University College of Medicine for use of the cryostat and optical microscope. Additionally, Mark Vanlandingham from the Army Research Labs in Aberdeen, MD, and Suzanne Maher from the Hospital for Special Surgery in New York, NY, provided valuable insight over the course of this research. Funding for this project was provided by the Department of Defense through the National Defense Science and Engineering Graduate Fellowship, in addition to the US Army Research Laboratory through the Army Materials Center of Excellence Program, contract W911NF-06-2-0013.

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N2 - An osmotic solution was used to evaluate poly(vinyl alcohol) (PVA) hydrogels as potential non-degradable soft tissue replacements in vitro. Osmotic solutions are necessary in order to mimic the swelling pressure observed in vivo for soft tissues present in load-bearing joints. In vitro studies indicated that PVA hydrogels experience minimal changes in swelling with a polymer concentration of 20 wt.% PVA in phosphate-buffered saline solution (0 atm) and between 30 and 35 wt.% PVA in osmotic solution with a pressure of 0.95 atm. Swelling in osmotic pressure solutions caused decreases in the equilibrium hydrogel hydration. An investigation of hydrogel compressive modulus indicated that PVA hydrogels are within the range of articular cartilage, meniscal tissue, and the temporomandibular joint disk. Furthermore, it is possible to tailor PVA hydrogels through careful modification of the polymer concentration and freeze-thaw cycles during hydrogel preparation to match both a desired swelling ratio and a desired compressive modulus or porosity. The microstructure of the PVA hydrogels was also evaluated as a function of freeze-thaw cycles and polymer concentration to give an insight into the processes occurring during synthesis and swelling in osmotic solutions.

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Analysis of the in vitro swelling behavior of poly(vinyl alcohol) hydrogels in osmotic pressure solution for soft tissue replacement

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