Abstract
A novel methodology for the efficient synthesis of [2.2.1] heterobicyclic pyroglutamates has been described. The key synthetic steps involve alkylation of amino acid-derived iminoesters with Baylis-Hillman bromide, RhCl 3-catalyzed exocyclic olefin isomerization, diastereoselective dihydroxylation, and regioselective lactonization. All the compounds were evaluated for their cytotoxicity using multiple myeloma cancer cell lines RPMI 8226.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 969-972 |
| Number of pages | 4 |
| Journal | Journal of Heterocyclic Chemistry |
| Volume | 50 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2013 |
All Science Journal Classification (ASJC) codes
- Organic Chemistry
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