Amur Maackia (Maackia amurensis) Seed Lectin History and Potential Effect on Cancer Progression, Inflammation and Viral Infection

Tyler J. Hellmig; Eamonn J. Brace; Amanda Greenspan; Christopher Laugier; Abhay Aradhya; Sayan Basu; Saumil Parikh; Katarzyna Jachimowska; Xiaoxuan Wu; Yongquan Shen; Kelly L. Hamilton; Gary S. Goldberg

doi:10.1201/9781003260028-9

Amur Maackia (Maackia amurensis) Seed Lectin History and Potential Effect on Cancer Progression, Inflammation and Viral Infection

Tyler J. Hellmig, Eamonn J. Brace, Amanda Greenspan, Christopher Laugier, Abhay Aradhya, Sayan Basu, Saumil Parikh, Katarzyna Jachimowska, Xiaoxuan Wu, Yongquan Shen, Kelly L. Hamilton, Gary S. Goldberg

Molecular Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Maackia amurensis seed lectin (MASL) is a natural product with an extensive history in medicine. Lectins such as MASL are unique pharmacologic agents that can survive gastrointestinal digestion. They can target specific sugar moieties on extracellular receptors to affect dynamic signaling pathways. In particular, MASL can bind sialic acid moieties on receptors including PDPN and ACE2 in order to inhibit molecular pathways that drive cancer progression, inflammation, and viral infection. Therefore, MASL is an enticing drug candidate with potential to treat pathologies including cancer, arthritis, psoriasis, and COVID. At the time of this writing, MASL is being studied in a phase 1 clinical trial aimed at oral cancer.

Original language	English (US)
Title of host publication	Ancient and Traditional Foods, Plants, Herbs and Spices used in Cancer
Publisher	CRC Press
Pages	89-102
Number of pages	14
ISBN (Electronic)	9781000902556
ISBN (Print)	9781032192536
DOIs	https://doi.org/10.1201/9781003260028-9
State	Published - Jan 1 2023

All Science Journal Classification (ASJC) codes

General Health Professions
General Medicine

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10.1201/9781003260028-9

Cite this

Hellmig, T. J., Brace, E. J., Greenspan, A., Laugier, C., Aradhya, A., Basu, S., Parikh, S., Jachimowska, K., Wu, X., Shen, Y., Hamilton, K. L., & Goldberg, G. S. (2023). Amur Maackia (Maackia amurensis) Seed Lectin History and Potential Effect on Cancer Progression, Inflammation and Viral Infection. In Ancient and Traditional Foods, Plants, Herbs and Spices used in Cancer (pp. 89-102). CRC Press. https://doi.org/10.1201/9781003260028-9

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abstract = "Maackia amurensis seed lectin (MASL) is a natural product with an extensive history in medicine. Lectins such as MASL are unique pharmacologic agents that can survive gastrointestinal digestion. They can target specific sugar moieties on extracellular receptors to affect dynamic signaling pathways. In particular, MASL can bind sialic acid moieties on receptors including PDPN and ACE2 in order to inhibit molecular pathways that drive cancer progression, inflammation, and viral infection. Therefore, MASL is an enticing drug candidate with potential to treat pathologies including cancer, arthritis, psoriasis, and COVID. At the time of this writing, MASL is being studied in a phase 1 clinical trial aimed at oral cancer.",

author = "Hellmig, {Tyler J.} and Brace, {Eamonn J.} and Amanda Greenspan and Christopher Laugier and Abhay Aradhya and Sayan Basu and Saumil Parikh and Katarzyna Jachimowska and Xiaoxuan Wu and Yongquan Shen and Hamilton, {Kelly L.} and Goldberg, {Gary S.}",

note = "Publisher Copyright: {\textcopyright} 2024 selection and editorial matter, Rajkumar Rajendram, Victor R. Preedy, and Vinood B. Patel; individual chapters, the contributors.",

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doi = "10.1201/9781003260028-9",

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Hellmig, TJ, Brace, EJ, Greenspan, A, Laugier, C, Aradhya, A, Basu, S, Parikh, S, Jachimowska, K, Wu, X, Shen, Y, Hamilton, KL & Goldberg, GS 2023, Amur Maackia (Maackia amurensis) Seed Lectin History and Potential Effect on Cancer Progression, Inflammation and Viral Infection. in Ancient and Traditional Foods, Plants, Herbs and Spices used in Cancer. CRC Press, pp. 89-102. https://doi.org/10.1201/9781003260028-9

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AU - Greenspan, Amanda

AU - Laugier, Christopher

AU - Aradhya, Abhay

AU - Basu, Sayan

AU - Parikh, Saumil

AU - Jachimowska, Katarzyna

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AU - Shen, Yongquan

AU - Hamilton, Kelly L.

AU - Goldberg, Gary S.

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AB - Maackia amurensis seed lectin (MASL) is a natural product with an extensive history in medicine. Lectins such as MASL are unique pharmacologic agents that can survive gastrointestinal digestion. They can target specific sugar moieties on extracellular receptors to affect dynamic signaling pathways. In particular, MASL can bind sialic acid moieties on receptors including PDPN and ACE2 in order to inhibit molecular pathways that drive cancer progression, inflammation, and viral infection. Therefore, MASL is an enticing drug candidate with potential to treat pathologies including cancer, arthritis, psoriasis, and COVID. At the time of this writing, MASL is being studied in a phase 1 clinical trial aimed at oral cancer.

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Amur Maackia (Maackia amurensis) Seed Lectin History and Potential Effect on Cancer Progression, Inflammation and Viral Infection

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