Amphiphilic polymer therapeutics: An alternative platform in the fight against antibiotic resistant bacteria

Haruko Takahashi, Gregory A. Caputo, Kenichi Kuroda

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

As we are on the cusp of the "post-antibiotic"era due to rapid spread of drug resistant bacteria, there is an urgent need for new antimicrobials that are not susceptible to bacterial resistance mechanisms. In this review, we will discuss the recent development of "polymer therapeutics"with antimicrobial activity. Learning from host-defence peptides, we propose the biomimetic design of synthetic polymers to target bacterial cell membranes, which act by compromising the membrane integrity. The discussion is extended to the future challenges and opportunities of antimicrobial polymers for clinical applications.

Original languageEnglish (US)
Pages (from-to)2758-2767
Number of pages10
JournalBiomaterials Science
Volume9
Issue number8
DOIs
StatePublished - Apr 21 2021

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Materials Science(all)

Fingerprint

Dive into the research topics of 'Amphiphilic polymer therapeutics: An alternative platform in the fight against antibiotic resistant bacteria'. Together they form a unique fingerprint.

Cite this