Amphiphilic PLGA-PEG-PLGA triblock copolymer nanogels varying in gelation temperature and modulus for the extended and controlled release of hyaluronic acid

Laura L. Osorno, Daniel E. Maldonado, Ricky J. Whitener, Alyssa N. Brandley, Alex Yiantsos, Jamie D.R. Medina, Mark E. Byrne

    Research output: Contribution to journalArticle

    1 Scopus citations

    Abstract

    Different compositional parameters of poly(D,L-lactic-co-glycolic acid)-b-poly(ethylene glycol) triblock copolymers (PLGA-PEG) were varied to analyze their effect on gel formation and mechanical properties. Parameters such as hydrophilic/hydrophobic ratio (PLGA/PEG ratio), lactic acid/glycolic acid ratio (LA/GA ratio), PEG molecular weight (PEG Mw), polymer solution concentration, copolymer molecular weight (Mw), and polydispersity index (PDI) were studied in this work. For copolymers with PEG Mw of 1500 Da, gelation temperature (34–37 °C) was affected by D,L-LA/GA ratio and Mw; while modulus was affected by LA/GA ratio, Mw, and Mn. Based on the parametric study, an injectable, thermoresponsive hyaluronic acid (HA) delivery platform was designed for ocular applications. PLGA-PEG copolymers with D,L-LA/GA ratio of 15/1, PLGA/PEG ratio of 2/1, PEG Mw of 1500 Da, and Mw of about 6 KDa gelled at 35 °C, were optically transparent, had a modulus less than 350 Pa and were used for HA release studies. This work also demonstrates, for the first time, an extended and controlled release of HA, beyond 2 weeks, from injectable hydrogels modified with a noncovalent interacting agent, poly(L-lysine). Smaller PLL chains slowed down the HA release kinetics, while larger PLL chains produced a release profile similar to the nonmodified hydrogels.

    Original languageEnglish (US)
    Article number48678
    JournalJournal of Applied Polymer Science
    Volume137
    Issue number25
    DOIs
    StatePublished - Jul 5 2020

    All Science Journal Classification (ASJC) codes

    • Chemistry(all)
    • Surfaces, Coatings and Films
    • Polymers and Plastics
    • Materials Chemistry

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