Alzheimer's/Vascular Spectrum Dementia: Classification in Addition to Diagnosis

Sheina Emrani, Melissa Lamar, Catherine C. Price, Victor Wasserman, Emily Matusz, Rhoda Au, Rodney Swenson, Robert Nagele, Kenneth M. Heilman, David J. Libon

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Alzheimer's disease (AD) and vascular dementia (VaD) are the two most common types of dementia. Although the combination of these disorders, called 'mixed' dementia, is recognized, the prevailing clinical and research perspective continues to consider AD and VaD as independent disorders. A review of recent neuropathological and neuropsychological literature reveals that these two disorders frequently co-occur and so-called 'pure' AD or VaD is comparatively rare. In addition, recent research shows that vascular dysfunction not only potentiates AD pathology, but that pathological changes in AD may subsequently induce vascular disorders. On the basis of these data, we propose that the neurobiological underpinnings underlying AD/VaD dementia and their neuropsychological phenotypes are best understood as existing along a clinical/pathological continuum or spectrum. We further propose that in conjunction with current diagnostic criteria, statistical modeling techniques using neuropsychological test performance should be leveraged to construct a system to classify AD/VaD spectrum dementia in order to test hypotheses regarding how mechanisms related to AD and VaD pathology interact and influence each other.

Original languageEnglish (US)
Pages (from-to)63-71
Number of pages9
JournalJournal of Alzheimer's Disease
Issue number1
StatePublished - 2020

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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