Alumina-promoted synthesis of N-aryl-1,2,4-triazoles from substituted hydrazines and imides

William C. Neuhaus, Gustavo Moura-Letts

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Herein we report the highly efficient, environmentally friendly alumina-promoted synthesis of N-aryl-1,2,4-triazoles with a wide variety of substitution patterns from commercially available hydrazines with symmetrical and unsymmetrical imides. Aromatic hydrazines with a variety of substitution patterns provided the corresponding 1,2,4-triazoles in very high yields. Unsymmetrical imides with a wide variety of functional groups also provide the respective triazoles with high yield and complete regioselectivities. The high productivity and mild conditions allow for the large-scale preparation of 1,2,4-triazoles.

Original languageEnglish (US)
Pages (from-to)4974-4977
Number of pages4
JournalTetrahedron Letters
Volume57
Issue number45
DOIs
StatePublished - 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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