All-dry synthesis and coating of methacrylic acid copolymers for controlled release

Kenneth K.S. Lau, Karen K. Gleason

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Initiated chemical vapor deposition (iCVD) is presented as an all-dry synthesis and coating method for applying methacrylic acid copolymers as pH-responsive controlled release layers. iCVD combines the strengths of liquid-phase chemical synthesis with a precision solvent-free chemical vapor deposition environment. Copolymers of methacrylic acid and ethyl acrylate were confirmed by a systematic shift in the carbonyl bond stretching mode with a shift in the comonomer ratio within the copolymer and by the ability to apply the Fineman-Ross copolymerization equation to describe copolymerization kinetics. Copolymers of methacrylic acid and ethylene dimethacrylate showed pH-dependent swelling behavior that was applied to the enteric release of fluorescein and ibuprofen.

Original languageEnglish (US)
Pages (from-to)429-434
Number of pages6
JournalMacromolecular Bioscience
Volume7
Issue number4
DOIs
StatePublished - Apr 10 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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