TY - JOUR
T1 - Advances in ultra-high-pressure and multi-dimensional liquid chromatography instrumentation and workflows
AU - De Vos, Jelle
AU - Stoll, Dwight
AU - Buckenmaier, Stephan
AU - Eeltink, Sebastiaan
AU - Grinias, James P.
N1 - Publisher Copyright:
© 2021 The Authors. Analytical Science Advances published by Wiley-VCH GmbH.
PY - 2021/4
Y1 - 2021/4
N2 - The present contribution discusses recent advances in ultra-high-pressure liquid chromatography (UHPLC) and multi-dimensional liquid chromatography (MDLC) technology. First, new developments in UHPLC column technology and system design are highlighted. The latter includes a description of a novel injector concept enabling method speed-up, emerging detectors, and instrument diagnostics approaches. Next, online MDLC workflows are reviewed and advances in modulation technology are highlighted. Finally, key applications published in 2020 are reviewed.
AB - The present contribution discusses recent advances in ultra-high-pressure liquid chromatography (UHPLC) and multi-dimensional liquid chromatography (MDLC) technology. First, new developments in UHPLC column technology and system design are highlighted. The latter includes a description of a novel injector concept enabling method speed-up, emerging detectors, and instrument diagnostics approaches. Next, online MDLC workflows are reviewed and advances in modulation technology are highlighted. Finally, key applications published in 2020 are reviewed.
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U2 - 10.1002/ansa.202100007
DO - 10.1002/ansa.202100007
M3 - Review article
AN - SCOPUS:85135213953
SN - 2628-5452
VL - 2
SP - 171
EP - 192
JO - Analytical Science Advances
JF - Analytical Science Advances
IS - 3-4
ER -