TY - JOUR
T1 - Advances in ultra-high-pressure and multi-dimensional liquid chromatography instrumentation and workflows
AU - De Vos, Jelle
AU - Stoll, Dwight
AU - Buckenmaier, Stephan
AU - Eeltink, Sebastiaan
AU - Grinias, James P.
N1 - Funding Information:
JPG acknowledges support for work in this area from the Chemical Measurement and Imaging Program in the National Science Foundation Division of Chemistry under Grant CHE‐2045023. SE acknowledges research project G033018N and support of this work by an Excellence of Science grant (30897864) of the Research Foundation Flanders and the Fonds de la Recherche Scientifique (FWO‐FRNS) is gratefully acknowledged. JDV acknowledges the FWO for support by a senior postdoctoral fellowship 12J6520N.
Funding Information:
JPG acknowledges support for work in this area from the Chemical Measurement and Imaging Program in the National Science Foundation Division of Chemistry under Grant CHE-2045023. SE acknowledges research project G033018N and support of this work by an Excellence of Science grant (30897864) of the Research Foundation Flanders and the Fonds de la Recherche Scientifique (FWO-FRNS) is gratefully acknowledged. JDV acknowledges the FWO for support by a senior postdoctoral fellowship 12J6520N.
Publisher Copyright:
© 2021 The Authors. Analytical Science Advances published by Wiley-VCH GmbH.
PY - 2021/4
Y1 - 2021/4
N2 - The present contribution discusses recent advances in ultra-high-pressure liquid chromatography (UHPLC) and multi-dimensional liquid chromatography (MDLC) technology. First, new developments in UHPLC column technology and system design are highlighted. The latter includes a description of a novel injector concept enabling method speed-up, emerging detectors, and instrument diagnostics approaches. Next, online MDLC workflows are reviewed and advances in modulation technology are highlighted. Finally, key applications published in 2020 are reviewed.
AB - The present contribution discusses recent advances in ultra-high-pressure liquid chromatography (UHPLC) and multi-dimensional liquid chromatography (MDLC) technology. First, new developments in UHPLC column technology and system design are highlighted. The latter includes a description of a novel injector concept enabling method speed-up, emerging detectors, and instrument diagnostics approaches. Next, online MDLC workflows are reviewed and advances in modulation technology are highlighted. Finally, key applications published in 2020 are reviewed.
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U2 - 10.1002/ansa.202100007
DO - 10.1002/ansa.202100007
M3 - Review article
AN - SCOPUS:85135213953
SN - 2628-5452
VL - 2
SP - 171
EP - 192
JO - Analytical Science Advances
JF - Analytical Science Advances
IS - 3-4
ER -