Adjuvant, pulse total parenteral nutrition and tumor response to cycle-specific and cycle-nonspecific chemotherapy

Michael H. Torosian, James L. Mullen, Elizabeth E. Miller, Katherine M. Wagner, T. Peter Stein, Gordon P. Buzby

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Previous work has demonstrated that substrate-induced alterations of tumor metabolism can be exploited to enhance tumor response to a cycle-specific chemotherapeutic agent (methotrexate). This study was designed to further investigate the biologic mechanism of this phenomenon by determination of tumor response to additional cycle-specific (Adriamycin) and cycle-nonspecific (Cytoxan) chemotherapeutic agents. Significant potentiation of tumor response during adjuvant total parenteral nutrition (TPN) was observed with methotrexate and Adriamycin but not with Cytoxan. This may imply that tumor sensitization by adjuvant TPN occurs by acceleration of the growth rate of proliferating tumor cells and not by recruitment of dormant tumor cells into the cell cycle.

Original languageEnglish (US)
Pages (from-to)291-299
Number of pages9
JournalSurgery
Volume94
Issue number2
StatePublished - Aug 1983
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery

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