Activation of blood coagulation in patients with major depressive disorder during euglycemic hyperinsulinemia

McDonald K. Horne; Paula K. Merryman; Ann M. Cullinane; June Cai; Pedro E. Martinez; Mitchel A. Kling; Philip W. Gold

doi:10.1016/j.thromres.2006.09.016

Activation of blood coagulation in patients with major depressive disorder during euglycemic hyperinsulinemia

McDonald K. Horne
, Paula K. Merryman
, Ann M. Cullinane
, June Cai
, Pedro E. Martinez
, Mitchel A. Kling
, Philip W. Gold

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

In the MDD patients but not the control group the logs of TAT and fVIII activity rose significantly during the period of experimental euglycemic hyperinsulinemia. The change in fVIII activity was not associated with a parallel change in fVIII antigen, suggesting that fVIII had become activated by thrombin. The logs of tPA and PAI-1 activity did not change significantly during the hyperinsulinemia in either group of subjects. The mechanism(s) underlying these observations is not clear.

Original language	English (US)
Pages (from-to)	517-521
Number of pages	5
Journal	Thrombosis Research
Volume	120
Issue number	4
DOIs	https://doi.org/10.1016/j.thromres.2006.09.016
State	Published - 2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

Hematology

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10.1016/j.thromres.2006.09.016

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title = "Activation of blood coagulation in patients with major depressive disorder during euglycemic hyperinsulinemia",

abstract = "In the MDD patients but not the control group the logs of TAT and fVIII activity rose significantly during the period of experimental euglycemic hyperinsulinemia. The change in fVIII activity was not associated with a parallel change in fVIII antigen, suggesting that fVIII had become activated by thrombin. The logs of tPA and PAI-1 activity did not change significantly during the hyperinsulinemia in either group of subjects. The mechanism(s) underlying these observations is not clear.",

author = "Horne, \{McDonald K.\} and Merryman, \{Paula K.\} and Cullinane, \{Ann M.\} and June Cai and Martinez, \{Pedro E.\} and Kling, \{Mitchel A.\} and Gold, \{Philip W.\}",

year = "2007",

doi = "10.1016/j.thromres.2006.09.016",

language = "English (US)",

volume = "120",

pages = "517--521",

journal = "Thrombosis Research",

issn = "0049-3848",

publisher = "Elsevier Ltd",

number = "4",

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TY - JOUR

T1 - Activation of blood coagulation in patients with major depressive disorder during euglycemic hyperinsulinemia

AU - Horne, McDonald K.

AU - Merryman, Paula K.

AU - Cullinane, Ann M.

AU - Cai, June

AU - Martinez, Pedro E.

AU - Kling, Mitchel A.

AU - Gold, Philip W.

PY - 2007

Y1 - 2007

N2 - In the MDD patients but not the control group the logs of TAT and fVIII activity rose significantly during the period of experimental euglycemic hyperinsulinemia. The change in fVIII activity was not associated with a parallel change in fVIII antigen, suggesting that fVIII had become activated by thrombin. The logs of tPA and PAI-1 activity did not change significantly during the hyperinsulinemia in either group of subjects. The mechanism(s) underlying these observations is not clear.

AB - In the MDD patients but not the control group the logs of TAT and fVIII activity rose significantly during the period of experimental euglycemic hyperinsulinemia. The change in fVIII activity was not associated with a parallel change in fVIII antigen, suggesting that fVIII had become activated by thrombin. The logs of tPA and PAI-1 activity did not change significantly during the hyperinsulinemia in either group of subjects. The mechanism(s) underlying these observations is not clear.

UR - https://www.scopus.com/pages/publications/34447624148

UR - https://www.scopus.com/pages/publications/34447624148#tab=citedBy

U2 - 10.1016/j.thromres.2006.09.016

DO - 10.1016/j.thromres.2006.09.016

M3 - Article

C2 - 17157901

AN - SCOPUS:34447624148

SN - 0049-3848

VL - 120

SP - 517

EP - 521

JO - Thrombosis Research

JF - Thrombosis Research

IS - 4

ER -

Activation of blood coagulation in patients with major depressive disorder during euglycemic hyperinsulinemia

Abstract

All Science Journal Classification (ASJC) codes

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