Activation induced deaminase: The importance of being specific

Harold C. Smith, Andrea Bottaro, Mark P. Sowden, Joseph E. Wedekind

Research output: Contribution to journalShort surveypeer-review

8 Scopus citations


Activation-induced deaminase (AID) is required for class switch recombination and somatic hypermutation in immunoglobulin genes. Although the preponderance of evidence suggests that AID functions by deaminating deoxycytidine in DNA, the question remains whether it can also deaminate cytidine in mRNA, as originally proposed based on its homology to RNA-editing enzymes. Recently, the biological relevance of assaying mammalian enzymes for DNA deaminase activity using Escherichia coli DNA as a reporter has been questioned, representing another round in the ongoing debate.

Original languageEnglish (US)
Pages (from-to)224-227
Number of pages4
JournalTrends in Genetics
Issue number6
StatePublished - Jun 1 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics


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