Acoustofluidic holography for micro- To nanoscale particle manipulation

Yuyang Gu, Chuyi Chen, Joseph Rufo, Chen Shen, Zeyu Wang, Po Hsun Huang, Hai Fu, Peiran Zhang, Steven A. Cummer, Zhenhua Tian, Tony Jun Huang

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Acoustic-based techniques can manipulate particles in a label-free, contact-free, and biocompatible manner. However, most previous work in acoustic manipulation has been constrained by axisymmetric patterns of pressure nodes and antinodes. Acoustic holography is an emerging technique that offers the potential to generate arbitrary pressure distributions which can be applied to particle manipulation with higher degrees of freedom. However, since current acoustic holography techniques rely on acoustic radiation forces, which decrease dramatically when the target particle size decreases, they have difficulty manipulating particles in the micro/nanoscale. Here, we introduce a holography technique that leverages both an arbitrary acoustic field and controllable fluid motion to offer an effective approach for manipulating micro/nano particles. Our approach, termed acoustofluidic holography (AFH), can manipulate a variety of materials, including cells, polymers, and metals, across sizes ranging from hundreds of micrometers to tens of nanometers.

Original languageEnglish (US)
Pages (from-to)14635-14645
Number of pages11
JournalACS Nano
Issue number11
StatePublished - Nov 24 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • General Engineering
  • General Physics and Astronomy


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