Acetyl nitrate mediated conversion of methyl ketones to diverse carboxylic acid derivatives

Joseph N. Capilato, Peter J. Pellegrinelli, Josephine Bernard, Logan Schnorbus, Shane Philippi, Joseph Mattiucci, Erik Hoy, Lark J. Perez

Research output: Contribution to journalArticlepeer-review

Abstract

The development of a novel acetyl nitrate mediated oxidative conversion of methyl ketones to carboxylic acid derivatives is described. By analogy to the haloform reaction and supported by experimental and computational investigation we propose a mechanism for this transformation.

Original languageEnglish (US)
Pages (from-to)5298-5302
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume19
Issue number24
DOIs
StatePublished - Jun 28 2021

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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