A tightly regulated molecular motor based upon T7 RNA polymerase

Richard T. Pomerantz; Ravi Ramjit; Zoher Gueroui; Christophe Place; Michael Anikin; Sanford Leuba; Jordanka Zlatanova; William T. McAllister

doi:10.1021/nl0509125

A tightly regulated molecular motor based upon T7 RNA polymerase

Richard T. Pomerantz, Ravi Ramjit, Zoher Gueroui, Christophe Place, Michael Anikin, Sanford Leuba, Jordanka Zlatanova, William T. McAllister

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Controlled movement of materials or molecules within the nanometer range is essential in many applications of nanotechnology. Here we report the capture, movement, and release of cargo molecules along DNA by a modified form of T7 RNA polymerase (RNAP) in a manner that is controlled by the sequence of the DNA. Using single-molecule methods, we visualize the assembly and manipulation of nanodevices and the ability to harness rotary and linear forces of the RNAP motor.

Original language	English (US)
Pages (from-to)	1698-1703
Number of pages	6
Journal	Nano Letters
Volume	5
Issue number	9
DOIs	https://doi.org/10.1021/nl0509125
State	Published - Sep 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl0509125

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AU - Pomerantz, Richard T.

AU - Ramjit, Ravi

AU - Gueroui, Zoher

AU - Place, Christophe

AU - Anikin, Michael

AU - Leuba, Sanford

AU - Zlatanova, Jordanka

AU - McAllister, William T.

PY - 2005/9

Y1 - 2005/9

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AB - Controlled movement of materials or molecules within the nanometer range is essential in many applications of nanotechnology. Here we report the capture, movement, and release of cargo molecules along DNA by a modified form of T7 RNA polymerase (RNAP) in a manner that is controlled by the sequence of the DNA. Using single-molecule methods, we visualize the assembly and manipulation of nanodevices and the ability to harness rotary and linear forces of the RNAP motor.

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JO - Nano Letters

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A tightly regulated molecular motor based upon T7 RNA polymerase

Abstract

All Science Journal Classification (ASJC) codes

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