@article{5934ff38ce474e8ba4682a2d0dbc2786,
title = "A review of two-dimensional liquid chromatography approaches using parallel column arrays in the second dimension",
abstract = "Multi-dimensional liquid chromatography techniques play an important role in the analysis of complex mixtures. The keys to maximizing peak capacity in these methods are fast sampling rates and sufficient complementarity between the first- (1D) and second- (2D) dimension separations. One way that these criteria have been met is by using 2D parallel column arrays. This review covers demonstrations of this approach in the literature that have been published over the past three decades. Two or more identical 2D columns can be operated in a sequential order to permit increased separation times and higher peak capacities in the second dimension without the concomitant decrease in sampling rate. The parallel column arrays can also be operated simultaneously to reduce total analysis time. Columns with different stationary phase chemistries can be used in the 2D column array to increase complementarity by utilizing specific stationary phases for various first dimension fractions. More recently, this type of platform has been used to automate the development of two-dimensional (2D) achiral-chiral LC methods. These strategies, as well as recent efforts toward the development of integrated, spatial multi-dimensional LC devices that include parallel column arrays, are discussed here.",
author = "Foster, {Samuel W.} and Deklin Parker and Sangeeta Kurre and John Boughton and Stoll, {Dwight R.} and Grinias, {James P.}",
note = "Funding Information: John Boughton is an undergraduate research assistant at Rowan University. His current research interests include HPLC and SFC, especially for use in multidimensional separations. He was the recipient of the Department of Chemistry and Biochemistry Undergraduate Analytical Chemistry Award, sponsored by the American Chemical Society. Funding Information: Samuel Foster is currently a graduate research assistant at Rowan University. His current research interests include capillary LC, open-source hardware development, and miniaturized instrumentation. He has received multiple awards for his research activities, including the Eastern Analytical Symposium Undergraduate Student Research Award and a National Science Foundation Graduate Research Fellowship. Funding Information: James Grinias is currently an Associate Professor in the Department of Chemistry & Biochemistry at Rowan University. His research interests include improving the throughput and efficiency of chromatographic separations and the miniaturization of chemical measurement techniques. James has received a number of awards for his work to date, including the Csaba Horv{\'a}th Young Scientist Award, a National Science Foundation CAREER grant, the 2021 American Chemical Society Satinder Ahuja Young Investigator in Separation Science Award, and the 2022 LCGC Emerging Leader in Chromatography Award. Funding Information: This work was supported by the Chemical Measurement and Imaging Program in the National Science Foundation Division of Chemistry under Grants CHE-2045023 (to JPG) and CHE-2003734 (to DRS). Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",
year = "2022",
month = oct,
day = "2",
doi = "10.1016/j.aca.2022.340300",
language = "English (US)",
volume = "1228",
journal = "Analytica Chimica Acta",
issn = "0003-2670",
publisher = "Elsevier",
}