A preliminary study of mechanically stress-induced changes in the extracellular matrix of the canine intervertebral disc

N. S. Vasan; E. W. Gutteling; C. K. Lee; M. Cibischino; J. R. Parsons

A preliminary study of mechanically stress-induced changes in the extracellular matrix of the canine intervertebral disc

N. S. Vasan
, E. W. Gutteling
, C. K. Lee
, M. Cibischino
, J. R. Parsons

Research output: Contribution to journal › Article › peer-review

Abstract

The intervertebral discs of a young (age, 3 years) and an old (age, 8 years) dog were isolated as motion segments and cyclically stressed in physiologic nondestructive axial compression loads. Chemical analysis of the matrix of the annulus fibrosus revealed a shift in proteoglycan molecular size from larger to smaller moieties for the older dog but not for the younger. These preliminary results may indicate an age-related inability of the disc to tolerate cyclic stress.

Original language	English (US)
Pages (from-to)	317-320
Number of pages	4
Journal	Transplantation
Volume	16
Issue number	3
State	Published - Mar 1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

Transplantation

Cite this

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title = "A preliminary study of mechanically stress-induced changes in the extracellular matrix of the canine intervertebral disc",

abstract = "The intervertebral discs of a young (age, 3 years) and an old (age, 8 years) dog were isolated as motion segments and cyclically stressed in physiologic nondestructive axial compression loads. Chemical analysis of the matrix of the annulus fibrosus revealed a shift in proteoglycan molecular size from larger to smaller moieties for the older dog but not for the younger. These preliminary results may indicate an age-related inability of the disc to tolerate cyclic stress.",

author = "Vasan, \{N. S.\} and Gutteling, \{E. W.\} and Lee, \{C. K.\} and M. Cibischino and Parsons, \{J. R.\}",

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journal = "Transplantation",

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AU - Vasan, N. S.

AU - Gutteling, E. W.

AU - Lee, C. K.

AU - Cibischino, M.

AU - Parsons, J. R.

PY - 1991/3

Y1 - 1991/3

N2 - The intervertebral discs of a young (age, 3 years) and an old (age, 8 years) dog were isolated as motion segments and cyclically stressed in physiologic nondestructive axial compression loads. Chemical analysis of the matrix of the annulus fibrosus revealed a shift in proteoglycan molecular size from larger to smaller moieties for the older dog but not for the younger. These preliminary results may indicate an age-related inability of the disc to tolerate cyclic stress.

AB - The intervertebral discs of a young (age, 3 years) and an old (age, 8 years) dog were isolated as motion segments and cyclically stressed in physiologic nondestructive axial compression loads. Chemical analysis of the matrix of the annulus fibrosus revealed a shift in proteoglycan molecular size from larger to smaller moieties for the older dog but not for the younger. These preliminary results may indicate an age-related inability of the disc to tolerate cyclic stress.

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M3 - Article

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AN - SCOPUS:84939098429

SN - 0041-1337

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JO - Transplantation

JF - Transplantation

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ER -

A preliminary study of mechanically stress-induced changes in the extracellular matrix of the canine intervertebral disc

Abstract

All Science Journal Classification (ASJC) codes

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