A preliminary study of mechanically stress-induced changes in the extracellular matrix of the canine intervertebral disc

N. S. Vasan, E. W. Gutteling, C. K. Lee, M. Cibischino, J. R. Parsons

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The intervertebral discs of a young (age, 3 years) and an old (age, 8 years) dog were isolated as motion segments and cyclically stressed in physiologic nondestructive axial compression loads. Chemical analysis of the matrix of the annulus fibrosus revealed a shift in proteoglycan molecular size from larger to smaller moieties for the older dog but not for the younger. These preliminary results may indicate an age-related inability of the disc to tolerate cyclic stress.

Original languageEnglish (US)
Pages (from-to)317-320
Number of pages4
JournalTransplantation
Volume16
Issue number3
StatePublished - Mar 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Transplantation

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