A poroelastic model describing nutrient transport and cell stresses within a cyclically strained collagen hydrogel

Benjamin L. Vaughan, Peter A. Galie, Jan P. Stegemann, James B. Grotberg

Research output: Contribution to journalArticle

5 Scopus citations


In the creation of engineered tissue constructs, the successful transport of nutrients and oxygen to the contained cells is a significant challenge. In highly porous scaffolds subject to cyclic strain, the mechanical deformations can induce substantial fluid pressure gradients, which affect the transport of solutes. In this article, we describe a poroelastic model to predict the solid and fluid mechanics of a highly porous hydrogel subject to cyclic strain. The model was validated by matching the predicted penetration of a bead into the hydrogel from the model with experimental observations and provides insight into nutrient transport. Additionally, the model provides estimates of the wall-shear stresses experienced by the cells embedded within the scaffold. These results provide insight into the mechanics of and convective nutrient transport within a cyclically strained hydrogel, which could lead to the improved design of engineered tissues.

Original languageEnglish (US)
Pages (from-to)2188-2198
Number of pages11
JournalBiophysical Journal
Issue number9
StatePublished - Nov 5 2013


All Science Journal Classification (ASJC) codes

  • Biophysics

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