A population based confidence set inference method for SNPS that regulate quantitative phenotypes

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The increased use of genome-wide association studies based on genetic maps consisting of hundreds of thousands of SNPs has prompted the need formethods that can be used in preliminary analyses to limit the number of SNPs investigated in follow-up studies. I introduce a Confidence Set Inference method for independent individuals that can be used as a first step in association studies to derive a set of SNPs that contribute at least a specific percentage to the total variance of a quantitative trait. The main advantage of the method is that it allows control over the confidence level with which one can identify genes with specific effects on the genetic variance of the trait of interest. Developed in the framework of linear models, the method can efficiently incorporate information on pertinent covariates. I investigate the properties of themethod through an extensive simulation study under various simple inheritance models and compare its performance to that of a standard association approach as it is implemented in the software package Merlin.

Original languageEnglish (US)
Title of host publicationOrdered Data Analysis, Modeling and Health Research Methods
EditorsPankaj K. Choudhary, Chaitra H. Nagaraja, Hon Keung Tony Ng
PublisherSpringer New York LLC
Pages235-244
Number of pages10
ISBN (Print)9783319254319
DOIs
StatePublished - Jan 1 2015
EventInternational Conference in Honor of H.N. Nagaraja for His 60th Birthday, 2014 - Dallas, United States
Duration: Mar 7 2014Mar 9 2014

Publication series

NameSpringer Proceedings in Mathematics and Statistics
Volume149
ISSN (Print)2194-1009
ISSN (Electronic)2194-1017

Other

OtherInternational Conference in Honor of H.N. Nagaraja for His 60th Birthday, 2014
CountryUnited States
CityDallas
Period3/7/143/9/14

All Science Journal Classification (ASJC) codes

  • Mathematics(all)

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  • Cite this

    Papachristou, C. (2015). A population based confidence set inference method for SNPS that regulate quantitative phenotypes. In P. K. Choudhary, C. H. Nagaraja, & H. K. T. Ng (Eds.), Ordered Data Analysis, Modeling and Health Research Methods (pp. 235-244). (Springer Proceedings in Mathematics and Statistics; Vol. 149). Springer New York LLC. https://doi.org/10.1007/978-3-319-25433-3_14