A high-resolution amperometric acetylcholine sensor based on nano- Assembled carbon nanotube and acetylcholinesterase thin films

Wei Xue, Tianhong Cui

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We demonstrate a carbon nanotube based high-resolution biosensor for acetylcholine sensing. Carbon nanotubes are deposited on a silicon wafer in a repeated fashion with layer-by-layer nano self-assembly technique. With nano-assembled acetylcholinesterase molecules on the surface, the carbon nanotube biosensor is capable of detecting acetylcholine at an ultra-low concentration of 100 pM. The sensitivity of the acetylcholine sensor is measured as 7.2 #A/decade. The real-time measurement shows the response time of the biosensor is approximately 6 sec. Both the carbon nanotube film and the acetylcholinesterase film are crucial in the sensing process. Due to its high resolution, fast response, small size, and low cost, the carbon nanotube biosensor has tremendous potential for applications in medical research and clinical diagnosis.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalJournal of Nano Research
Issue number1
DOIs
StatePublished - 2008

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Physics and Astronomy(all)

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