Timothy Vaden

  • 1144 Citations
  • 18 h-Index
20012019
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Personal profile

Research interests

Research Expertise: 
Physical Chemistry | Biophysical Chemistry | Spectroscopy

My research utilizes tools of experimental physical chemistry to investigate metal ion-molecule interactions, characterize the proton solvation and conduction mechanisms in ionic liquid solutions, and protein stability in aqueous ionic liquids.

My lab has four main research projects underway:

Characterizing the solvation of protons in ionic liquids and the proton transportation mechanisms in acidic ionic liquid solutions.

Understanding the behavior of proteins and antibiotics in aqueous ionic liquid solutions.

Evaluating competitive metal ion chelation by small molecules in the presence of peptides.

Synthesizing and evaluating different hydrogen-generating electrocatalysts.

Member of:
American Chemical Society (www.acs.org)

Recent Academic Projects:
Investigations of TMG-biomolecule ILs for stabilizing proteins, investigations of ILs for enhancing antibiotic activities

Education/Academic qualification

Doctor of Philosophy, doctorate

Bachelor of Science, Bachelor

Fingerprint Dive into the research topics where Timothy Vaden is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Ionic Liquids Chemical Compounds
Ionic liquids Engineering & Materials Science
Ions Chemical Compounds
Alkali Metals Chemical Compounds
Infrared spectroscopy Chemical Compounds
Peptides Chemical Compounds
Metal ions Chemical Compounds
Gases Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2001 2019

  • 1144 Citations
  • 18 h-Index
  • 44 Article
  • 1 Conference article

Activity and characterization of a pH-sensitive antimicrobial peptide

Hitchner, M. A., Santiago-Ortiz, L. E., Necelis, M. R., Shirley, D. J., Palmer, T. J., Tarnawsky, K. E., Vaden, T. & Caputo, G., Oct 1 2019, In : Biochimica et Biophysica Acta - Biomembranes. 1861, 10, 182984.

Research output: Contribution to journalArticle

Peptides
Membranes
Assays
Agglomeration
Lipids

Correlating lipid membrane permeabilities of imidazolium ionic liquids with their cytotoxicities on yeast, bacterial, and mammalian cells

Cook, K., Tarnawsky, K., Swinton, A. J., Yang, D. D., Senetra, A. S., Caputo, G. A., Carone, B. R. & Vaden, T. D., Jun 2019, In : Biomolecules. 9, 6, 251.

Research output: Contribution to journalArticle

Open Access
Ionic Liquids
Cytotoxicity
Membrane Lipids
Yeast
Permeability

Effects of ionic liquid alkyl chain length on denaturation of myoglobin by anionic, cationic, and zwitterionic detergents

Lee, J. Y., Selfridge, K. M., Kohn, E. M., Vaden, T. D. & Caputo, G. A., Jul 2019, In : Biomolecules. 9, 7, 264.

Research output: Contribution to journalArticle

Open Access
Ionic Liquids
Denaturation
Myoglobin
Chain length
Detergents

Structural Destabilization of Azurin by Imidazolium Chloride Ionic Liquids in Aqueous Solution

Acharyya, A., Digiuseppi, D., Stinger, B. L., Schweitzer-Stenner, R. & Vaden, T., Aug 15 2019, In : Journal of Physical Chemistry B. 123, 32, p. 6933-6945 13 p.

Research output: Contribution to journalArticle

Azurin
Ionic Liquids
destabilization
Ionic liquids
chlorides

An activity transition from NADH dehydrogenase to NADH oxidase during protein denaturation

Huston, S., Collins, J., Sun, F., Zhang, T., Vaden, T., Zhang, Y. H. P. & Fu, J., May 1 2018, In : Biotechnology and Applied Biochemistry. 65, 3, p. 286-293 8 p.

Research output: Contribution to journalArticle

Protein Denaturation
Flavin Mononucleotide
Denaturation
Niacinamide
Diphosphates