Projects per year
Personal profile
Research interests
Research Expertise:
Physical Chemistry | Biophysical Chemistry | Spectroscopy
My research utilizes tools of experimental physical chemistry to investigate metal ion-molecule interactions, characterize the proton solvation and conduction mechanisms in ionic liquid solutions, and protein stability in aqueous ionic liquids.
My lab has four main research projects underway:
Characterizing the solvation of protons in ionic liquids and the proton transportation mechanisms in acidic ionic liquid solutions.
Understanding the behavior of proteins and antibiotics in aqueous ionic liquid solutions.
Evaluating competitive metal ion chelation by small molecules in the presence of peptides.
Synthesizing and evaluating different hydrogen-generating electrocatalysts.
Member of:
American Chemical Society (www.acs.org)
Recent Academic Projects:
Investigations of TMG-biomolecule ILs for stabilizing proteins, investigations of ILs for enhancing antibiotic activities
Education/Academic qualification
Doctor of Philosophy, doctorate
Bachelor of Science, Bachelor
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Projects
- 1 Finished
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RUI: Combining experiments and simulations to optimize biomolecular ionic liquids for protein stabilization
Vaden, T. (PI)
National Science Foundation (NSF)
8/15/19 → 7/31/23
Project: Other project
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Lipid bilayer permeabilities and antibiotic effects of tetramethylguanidinium and choline fatty acid ionic liquids
Dutta, A., Burrell, B., Prajapati, E., Cottle, S., Maurer, H. Y., Urban, M. J., Pennock, S. R., Muhamed, A. M., Harris, J., Flores, Y., Staman, L., Carone, B. R., Caputo, G. A. & Vaden, T. D., Jan 2025, In: Biochimica et Biophysica Acta - Biomembranes. 1867, 1, 184393.Research output: Contribution to journal › Article › peer-review
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Elucidating the stabilization mechanism of a K+-depleted c-MYC DNA G-quadruplex in hydrophobic imidazolium-based ionic liquids using spectroscopy coupled with molecular dynamics simulations
Paradis, N. J., Clark, A., Dutta, A., Gogoj, H., Vaden, T. D. & Wu, C., Apr 2024, In: Journal of Molecular Liquids. 399, 124407.Research output: Contribution to journal › Article › peer-review
Open Access -
Sequence-specific destabilization of azurin by tetramethylguanidinium-dipeptide ionic liquids
Patel, R., Clark, A. K., DeStefano, G., DeStefano, I., Gogoj, H., Gray, E., Patel, A. Y., Hauner, J. T., Caputo, G. A. & Vaden, T. D., Jul 2022, In: Biochemistry and Biophysics Reports. 30, 101242.Research output: Contribution to journal › Article › peer-review
Open Access -
To probe the binding of TMPyP4 to c-MYC G-quadruplex with in water and in imidazolium-based ionic liquids using spectroscopy coupled with molecular dynamics simulations
Paradis, N. J., Clark, A., Gogoj, H., Lakernick, P. M., Vaden, T. D. & Wu, C., Nov 1 2022, In: Journal of Molecular Liquids. 365, 120097.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Effects of Ionic Liquids on Laccase from Trametes versicolor
Patel, A. Y., Clark, A. K., Paradis, N. J., Amin, M., Vaden, T. D., Wu, C. & Caputo, G. A., Dec 2021, In: Biophysica. 1, 4, p. 429-444 16 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations