Thomas Keck

  • 401 Citations
  • 13 h-Index
20062020

Research output per year

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Personal profile

Research interests

Research Expertise:
Pharmacology | Neuroscience | Biochemistry

I am interested in developing new medications for neuropsychiatric disorders, including Alzheimer’s disease, schizophrenia, ADHD, pain, anxiety, and a particular interest in drug addiction. My lab works closely with medicinal chemists to design and test new drug-like molecules, combining molecular and behavioral pharmacology methods to evaluate the preclinical potential of new compounds designed to target the dopamine D4 receptor, the µ opioid receptor, and the trace amine-associated receptor 1, among others.

Honors and Awards:
2017 Maharaj Ticku Memorial Travel Fellowship for New Investigators Award, Behavior, Biology and Chemistry Conf.
2015 Frances R. Lax Faculty Development Award, Rowan University
2013 Mentoring Award for Fellows, NIDA-IRP, NIH
2013 Postdoctoral Mentor Award, NIH
2012 & 2013 Fellows’ Award for Research Excellence, NIH

Member of:
American Society for Pharmacology and Experimental Therapeutics https://www.aspet.org/
Pharmacology Society (Councilor) https://www.aspet.org/MAPS/
Philadelphia Chapter of the Society for Neuroscience http://pcsfn.com/

Education/Academic qualification

Doctor of Philosophy, doctorate

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Projects

Research Output

  • 401 Citations
  • 13 h-Index
  • 20 Article
  • 1 Chapter

Cognitive and behavioral effects of brief seizures in mice

Batterman, A. I., DeChiara, J., Islam, A., Brenner, M. B., Fischer, B. D., Buono, R. J., Keck, T. & Ferraro, T., Sep 1 2019, In : Epilepsy and Behavior. 98, p. 249-257 9 p.

Research output: Contribution to journalArticle

  • Dopamine D4 Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy

    Keck, T. M., Free, R. B., Day, M. M., Brown, S. L., Maddaluna, M. S., Fountain, G., Cooper, C., Fallon, B., Holmes, M., Stang, C. T., Burkhardt, R., Bonifazi, A., Ellenberger, M. P., Newman, A. H., Sibley, D. R., Wu, C. & Boateng, C. A., Apr 11 2019, In : Journal of Medicinal Chemistry. 62, 7, p. 3722-3740 19 p.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia

    Del Bello, F., Ambrosini, D., Bonifazi, A., Newman, A. H., Keck, T. M., Giannella, M., Giorgioni, G., Piergentili, A., Cappellacci, L., Cilia, A., Franchini, S. & Quaglia, W., May 15 2019, In : ACS chemical neuroscience. 10, 5, p. 2222-2228 7 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R)

    Kumar, V., Moritz, A. E., Keck, T. M., Bonifazi, A., Ellenberger, M. P., Sibley, C. D., Free, R. B., Shi, L., Lane, J. R., Sibley, D. R. & Newman, A. H., Feb 23 2017, In : Journal of Medicinal Chemistry. 60, 4, p. 1478-1494 17 p.

    Research output: Contribution to journalArticle

  • 20 Scopus citations

    The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1Areceptor over α1-adrenoceptor and D2-like receptor subtypes

    Del Bello, F., Bonifazi, A., Giannella, M., Giorgioni, G., Piergentili, A., Petrelli, R., Cifani, C., Micioni Di Bonaventura, M. V., Keck, T. M., Mazzolari, A., Vistoli, G., Cilia, A., Poggesi, E., Matucci, R. & Quaglia, W., Jan 1 2017, In : European Journal of Medicinal Chemistry. 125, p. 233-244 12 p.

    Research output: Contribution to journalArticle

  • 9 Scopus citations